This article has been corrected: In Figure 9, the panel C image contains an accidental partial overlap of the panel D image. The corrected Figure 9, produced using the original data, is shown below. The authors declare that these corrections do not change the results or conclusions of this paper.
Figure 9. Knockdown effect of siRNA-FA-PEG-COL nanoparticles targeting KHSRP-bound snoRNAs on cell motility and invasion in the orthotopic murine model of PDAC.
(A) Development of carcinomatosis in S2-013 tumor-bearing mice treated with scrambled control siRNA-FA-PEG-COL nanoparticles (Scr) and target siRNA-FA-PEG-COL nanoparticles against SNORA18 (si-snora18) and SNORA22 (si-snora22). Arrow, primary tumor; arrowheads, dissemination nodules in the abdominal cavity. (B–D) Hematoxylin and eosin staining of representative sections of S2-013-derived PDAC tumor tissues in mice treated with scrambled control siRNA-FA-PEG-COL nanoparticles showing areas of regional invasion of the retroperitoneum (B) and distant metastases to the lung (C) and liver (D). Original magnification: 200×.
Original article: Oncotarget. 2020; 11:131–147. 131-147. https://doi.org/10.18632/oncotarget.27413