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. Author manuscript; available in PMC: 2023 Mar 1.
Published in final edited form as: Gut. 2022 Sep 9;72(3):581–589. doi: 10.1136/gutjnl-2022-327777

Table 2.

Performance of liver stiffness by vibration-controlled transient elastography for predicting progression to cirrhosis among patients with baseline bridging (F3) fibrosis and liver-related clinical events among patients with cirrhosis (F4)

Progression to Cirrhosis (F4) in Patients with Bridging Fibrosis (F3) (n=664) Liver-Related Clinical Events Among Patients with Cirrhosis (F4) (n=734)
c-statistic (95% CI) 0.72 (0.66, 0.77) 0.77 (0.67, 0.87)
Optimal threshold ≥ 16.6 kPa ≥ 30.7 kPa
Sensitivity (95% CI) 58% (48, 68) (60/103) 70% (50, 86) (19/27)
Specificity (95% CI) 76% (73, 80) (428/561) 79% (75, 81) (555/707)
PPV (95% CI) 31% (25, 38) (60/193) 11% (7, 17) (19/171)
NPV (95% CI) 91% (88, 93) (428/471) 99% (97, 99) (555/563)

NPV, negative predictive value; PPV, positive predictive value.

95% CI for sensitivity, specificity, PPV, and NPV are based on exact limits.