Skip to main content
. Author manuscript; available in PMC: 2023 Nov 2.
Published in final edited form as: Neuron. 2022 Nov 2;110(21):3566–3581. doi: 10.1016/j.neuron.2022.10.024

Figure 1:

Figure 1:

Anatomy and functions of the perivascular space at the level of a postcapillary venule.

A: Location of perivascular spaces within the brain. B: Anatomical model of a perivascular space at the level of the postcapillary venule. C: Functional model of immune cell trafficking within the perivascular space of a postcapillary venule, including the relevant molecules identified to date. Note that for a more comprehensive list of adhesion molecules on the endothelium, we refer to other reviews.112–114.

Abbreviations: AP, amino peptidase; BM, basement membrane; EMMPRIN, Extracellular matrix metalloproteinase inducer; Endo, endothelial cells; IL, interleukin; JAM-A, junctional adhesion molecule-A; Leuko, leukocytes; MΦ, macrophage; MMP, matrix metalloproteinase; PECAM, platelet endothelial fundingcell adhesion molecule; PVM, perivascular macrophage; TIMP, tissue inhibitor metalloproteinase; TNFR, tumor necrosis factor receptor.