Figure 10.

Changes in glucose, D-BHB and FOXO1 and FOXO3a levels in mice treated with a ketogenic diet. Glucose levels (A) and D-BHB levels (B) in blood of mice treated with a control diet (CD) or ketogenic diet (KD). Representative Western blots and quantification of FOXO3a/β-actin and FOXO1/β-actin in the cortex (C,E) and the hippocampus (D,F) of mice treated for 2 weeks with CD or KD. Data are expressed as Mean ± SEM from 8 individuals per group. Box-plot data (A,B) are expressed as median (line), 25th and 75th percentiles (bound of box) and minimum and maximum values (whiskers) from 8 individuals per group. Data from A and B were analyzed by two-way ANOVA followed by Tukey’s post-hoc test. Data from C to F were analyzed by Student’s t-test. * p < 0.05 vs. control diet.