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. 2022 Dec 20;42(7):530–540. doi: 10.1038/s41388-022-02569-3

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A The cumulative incidence of colorectal cancer (CRC) was increased by 73% in appendectomy cases compared with controls during the 20 years follow-up. B The adjusted sub-distribution hazard ratio (SHR) for CRC development stratified by age (≤50 years old, 50–60 years old, 60–70 years old, and >70 years old). C The temporal trends of the adjusted SHR for CRC development over the 20 follow-up years in appendectomy cases compared with controls.