Table 2.

The SIA score predicts OS and RFS in 286 stage I-III colon cancer patients.

Co-variable	Overall survival		Recurrence-free survival
	HR (95% CI)	p value	HR (95% CI)	p valuea
Unadjusted Cox model, SIA
SIA, three-category
Intermediate vs low	0.65 (0.44–0.97)	0.037	0.65 (0.44–0.95)	0.026
High vs low	0.43 (0.28–0.65)	0.00014	0.46 (0.30–0.69)	0.00022
Unadjusted Cox model, IS
IS, three-category
Intermediate vs low	0.47 (0.29–0.76)	0.0020	0.49 (0.31–0.78)	0.0030
High vs low	0.51 (0.29–0.90)	0.020	0.49 (0.29–0.85)	0.011
Multivariable Cox model
SIA, three-category
Intermediate vs low	0.65 (0.42–0.99)	0.047	0.65 (0.43–0.98)	0.037
High vs low	0.52 (0.33–0.81)	0.0040	0.55 (0.36–0.84)	0.0059
IS, three-category
Intermediate vs low	0.46 (0.27–0.77)	0.0030	0.49 (0.30–0.80)	0.0041
High vs low	0.62 (0.33–1.16)	0.13	0.62 (0.34–1.12)	0.11
T stage
T2 vs T1	1.31 (0.44–3.95)	0.63	1.12 (0.37–3.36)	0.84
T3 vs T1	1.20 (0.56–2.59)	0.64	1.25 (0.58–2.67)	0.57
T4 vs T1	3.51 (1.52–8.09)	0.0032	2.97 (1.30–6.79)	0.010
N stage
N+ vs N0	1.74 (1.18–2.57)	0.0048	2.13 (1.47–3.08)	<0.0001
Age
Age > 75 vs Age ≤ 75 years	3.49 (2.40–5.09)	<0.0001	2.60 (1.82–3.72)	<0.0001
Sex
Male vs female	0.85 (0.58–1.23)	0.38	0.90 (0.63–1.28)	0.56
MSI status
MMR deficient vs proficient	0.82 (0.50–1.35)	0.44	0.95 (0.60–1.51)	0.84
MMR missing vs proficient	1.48 (0.59–3.73)	0.41	1.18 (0.47–2.93)	0.73

Relative hazards, estimated in univariable (for SIA and IS separately) and multivariable (SIA, IS and clinical risk factors) Cox proportional hazards models, using OS and RFS as the endpoints.

MSI, microsatellite instability; MMR, mismatch repair; SIA, signature of immune activation; IS, Immunoscore; HR, hazard ratio; CI, confidence interval.

^aWald p value.