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Baicalein modulates cell cycle regulatory proteins in G2/M phase via the ATM/CHK2/CDC25C signaling axis in ovarian cancer cells. (A) SKOV-3 and TOV-21G cells were treated with 50–200 μM baicalein for 48 h. (B) SKOV-3 cells were treated with 100 μM baicalein for 12–72 h. Immunoblotting showed the effect of baicalein on the protein levels of phospho-CHK2 and phospho-CDC25C, as well as the protein levels of CHK2, CDC25C, CDK1 and cyclin B1. β-actin was used as a loading control.
