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. 2023 Feb 1;15(3):734. doi: 10.3390/nu15030734

Figure 2.

Figure 2

Molecular interaction of cell cycle components with the circadian core clock. (A) CLOCK:BMAL1 complex is able to control the transcription of the cell cycle-related gene Wee-1 directly and encodes a protein kinase that inactivates the CDC2/Cyclin B1 complex. Hence, G2-M transition and cell cycle progression are regulated. (B) CLOCK:BMAL1 transcriptional activation of the genes encoding Cyclin D1 and C-MYC affects cell proliferation and differentiation. (C) PER1 complex with the ATM kinase and the checkpoint kinase Chk2 impinges DNA repair, cell cycle arrest, and/or apoptosis [28].