Table 1.
Neonatal and clinical characteristics of the cohort.
| Total (n = 38) |
Cholestasis Resolution | Infants with Gut Disease Cholestasis Resolution |
Infants without Gut Disease Cholestasis Resolution |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| No (n = 10) |
Yes (n = 28) |
p | No (n = 5) |
Yes (n = 22) |
p | No (n = 5) |
Yes (n = 6) |
p | ||
| Gestational age (weeks) | 31.1 [27.0; 34.3] |
27.7 [25.1; 34.2] |
31.6 [27.0; 34.1] |
0.57 | 27.3 [24.4; 27.6] |
31.1 [27.0; 33.7] |
0.08 | 34.4 [33.6; 36.6] |
34.4 [30.7; 35.7] |
0.86 |
| Prematurity | 92.1% (35) | 90.0% (9) | 92.9% (26) | 0.99 | 100% (5) | 95.5% (21) | >0.99 | 80% (4) | 83.3% (5) | >0.99 |
| Sex (male) | 44.7% (17) | 40.0% (4) | 46.4% (13) | 0.99 | 20% (1) | 50% (11) | 0.34 | 60% (3) | 33.3% (2) | 0.57 |
| BW (g) | 1390 [743; 2298] |
980.0 [707.0; 2268] |
1695 [866.0; 2308] |
0.45 | 736 [645; 830] |
965 [799; 2138] |
0.06 | 2290 [2200; 2300] |
2365 [1888; 3068] |
0.47 |
| Fenton’s BW (percentile) | 49.5 [22.5; 78.2] |
49.5 [22.5; 65.5] |
48.5 [23.2; 79.5] |
0.58 | 51.0 [27.0; 66.0] |
43.0 [10.5; 74.5] |
0.85 | 48.0 [21.0; 64.0] |
74.0 [42.8; 89.5] |
0.20 |
| ELBW | 47.4% (18) | 50.0% (5) | 46.4% (13) | 0.99 | 80% (4) | 54.5% (12) | 0.62 | 20% (1) | 16.7% (1) | >0.99 |
| NEC | 36.8% (14) | 40.0% (4) | 35.7% (10) | 0.99 | 100% (5) | 45.5% (10) | 0.047 | 0% (0) | 16.7% (1) | >0.99 |
| IVH | 23.7% (9) | 40.0% (4) | 17.9% (5) | 0.21 | 60% (3) | 18.2% (4) | 0.09 | 20% (1) | 16.7% (1) | >0.99 |
| BPD | 50.0% (19) | 70.0% (7) | 42.9% (12) | 0.27 | 80% (4) | 40.9% (9) | 0.17 | 60% (3) | 33.3% (2) | 0.57 |
| Coagulopathy | 15.8% (6) | 30.0% (3) | 10.7% (3) | 0.31 | 20% (1) | 9.1% (2) | 0.47 | 40% (2) | 16.7% (1) | 0.55 |
| Cholestasis diagnoses (DOL) | 15.0 [10.0; 24.8] |
23.5 [11.2; 26.5] |
14.5 [9.8; 19.0] |
0.42 | 25 [23.0; 27.0] |
14.5 [10.5; 25.0] |
0.15 | 10 [9.0; 24] |
13 [8.0; 16.5] |
0.78 |
| Initial conjugated bilirubin (mg/dL) | 3.8 [2.6; 6.0] |
5.1 [3.1; 11.3] |
3.3 [2.6; 5.7] |
0.11 | 4.0 [2.8; 4.1] |
3.1 [2.6; 4.0] |
0.51 | 11.7 [6.0; 17.1] |
4.7 [3.3; 5.9] |
0.17 |
| HA before OVTM | 81.6% (31) | 100% (10) | 75.0% (21) | 0.16 | 100% (5) | 81.8% (18) | 0.56 | 100% (5) | 50% (3) | 0.18 |
| Sepsis before OVTM | 76.3% (29) | 70.0% (7) | 78.6% (22) | 0.67 | 100% (5) | 81.8% (18) | 0.56 | 40% (2) | 66.7% (4) | 0.57 |
| Death | 23.7% (9) | 80.0% (8) | 3.6% (1) | <0.001 | 80% (4) | 5% (1) | 0.002 | 80% (4) | 0% (0) | 0.015 |
Data show median and interquartile range (Q1; Q3) for quantitative variables and percentage and sample size (n) for qualitative variables. The p-Values (p) were extracted by chi-squared test or Mann–Whitney U test among cholestasis resolution groups. BW: birth weight; ELBW: extremely low birth weight; NEC: Necrotizing enterocolitis; IVH: Intraventricular hemorrhage; BPD: Bronchopulmonary dysplasia; DOL: days of life; HA: hemodynamic alterations; OV: Omegaven.