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The metabolic stability of 14b and CA-4.
| Compd. | Time/min, Remaining% | t1/2, min | ||||||
|---|---|---|---|---|---|---|---|---|
| 30 | 60 | 90 | 120 | 150 | 180 | 240 | ||
| 14b | 96.18% | 91.38% | 84.14% | 74.45% | 67.75% | 56.17% | 43.43% | 198 |
| CA-4 | 70.2% | 28.3% | 20.5% | 18.7% | NT a | NT | NT | ND b |
a NT: not tested because of the fast metabolic rate of CA-4; b ND: not determined.
