Table 1.

Single-CpG associations with WMH burden in the discovery sample (P < 1 × 10^–5)

CpG	Chr:Position (hg19)	Nearest gene	Reduced model					Full model
			n	Z	P	Q	FDR	n	Z	P
cg24202936	11:50257256	SEPTIN7P11	5359	5.38	7.58 × 10–8	0.03	0.04	4930	5.28	1.30 × 10–7
cg17417856	19:50191637	PRMT1;ADM5	4917	–4.95	7.42 × 10–7	0.15	0.28	4526	–4.40	1.11 × 10–5
cg01506471	7:3990479	SDK1	5359	–4.81	1.52 × 10–6	0.21	0.3	4930	–4.00	6.41 × 10–5
cg14547240	4:15428750	C1QTNF7	5359	–4.71	2.48 × 10–6	0.25	0.3	4930	–4.17	3.10 × 10–5
cg21547371	3:52869521	MUSTN1	5359	–4.65	3.30 × 10–6	0.25	0.3	4930	–4.06	4.95 × 10–5
cg03116124	1:231293208	TRIM67	5129	–4.64	3.54 × 10–6	0.25	0.31	4700	–4.58	4.63 × 10–6
cg06809326	17:20799526	CCDC144NL-AS1	5359	4.57	4.80 × 10–6	0.28	0.34	4930	3.44	5.88 × 10–4
cg13476133	7:44185646	GCK	5359	4.55	5.46 × 10–6	0.28	0.36	4930	4.03	5.65 × 10–5
cg14133539	9:104568	FOXD4	4917	–4.53	5.98 × 10–6	0.28	0.38	4526	–4.45	8.41 × 10–6
cg17577122	22:19511967	CLDN5	5359	4.50	6.88 × 10–6	0.29	0.4	4930	4.79	1.68 × 10–6
cg23586595	4:84034390	PLAC8	5359	4.45	8.45 × 10–6	0.32	0.43	4930	3.93	8.36 × 10–5
cg23054394	3:140784675	SPSB4	5359	–4.42	9.88 × 10–6	0.34	0.45	4930	–4.01	6.07 × 10–5

The reduced model is adjusted for age, sex, study site (if applicable), total (intra)cranial volume (cm³), white blood cell proportion (%), technical covariates and genetic principal components. The full model is additionally adjusted for BMI, smoking status and systolic and diastolic blood pressure measures. Chr = chromosome; EA = European ancestry; FDR = local false discovery rate value; n = number of subjects tested for the CpG; P = P-value; Q = Q-value; SE = standard error; Z = Z-score.