Abstract
Complex formation processes of tetrasulfosubstituted cobalt(II) phthalocyanine with ORF3a accessory protein of SARS-CoV-2 coronavirus were studied. The interaction of ORF3a protein with SARS-CoV-2 virus with tetrasulfosubstituted cobalt(II) phthalocyanine affords a stable complex in which metallophthalocyanine exists in the monomeric form. The complex formation induces slight changes in the secondary structure of the protein by increasing the fraction of disordered fragments of the polypeptide chain. The photoirradiation of the complex of ORF3a protein of SARS-CoV-2 virus with tetrasulfosubstituted cobalt(II) phthalocyanine leads to the photooxidation of amino acid residues of the protein.
Key words: phthalocyanine, protein, virus SARS-CoV-2, complex formation, photooxidation
Footnotes
Oscar Iosifovich Koifman, born in 1944, Doctor of Chemical Sciences, Professor, President of the Ivanovo State University of Chemistry and Technology (Ivanovo, Russia), leading scientist in the field of macroheterocyclic tetrapyrrole compounds, honored worker of science of the Russian Federation, awarded by prizes of the President of RF and Government of RF and the Order of Honor, elected the Full Member (Academician) of the Russian Academy of Sciences in 2022 (for more detailed information, see Ref. 1).
Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, Vol. 72, No. 1, pp. 0233–0238, January, 2023.
This work was financially supported by the Russian Foundation for Basic Research (Project No. 20-04-60108).
No human or animal subjects were used in this research.
The authors declare no competing interests.
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