Table 2.

Summary of MC patient information.

Pt	Age	Sex	ICI history	Primary Tumor	Disease tissue TCR sequencing	Brief Clinical Course
1	75	M	Ipilimumab + Nivolumab	Renal cell carcinoma	Cardiac biopsy; Autopsy: diaphragm, psoas	Pt 1 presented to the emergency department with chest pain 3wks post initiation of ICI and was found to have ventricular tachycardia (VT), and elevated troponin. EMB confirmed MC. Pt’s clinical course was complicated by cardiogenic shock, acute hypoxic respiratory failure and acute renal failure, despite high dose steroids. The pt and family declined further aggressive treatment with curative intent and opted for palliative extubation.
2	64	M	Nivolumab	Small cell lung cancer	Autopsy: RV, LV, IVS, deltoid, diaphragm	Pt2 was admitted to the hospital with recurrent VT and elevated troponin. Pt was found to have a dilated RV on echo. Prednisone treatment with initiated. EMB was complicated by RV perforation leading to acute cardiac tamponade, left atrial thrombus, and rapid clinical deterioration. Family opted for palliative extubation.
3	78	M	Pembrolizumab	Lung adenocarcinoma	Cardiac biopsy	Pt3 was evaluated for fatigue and myalgias and was found to have elevated troponin. The patient was admitted, started on high dose steroids and MC was confirmed by EMB. Patient recovered with steroid treatment and did not experience recurrence of MC. The patient died 5 months later in home hospice due to complications related to a hemothorax which was potentially related to underlying malignancy.