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. 2023 Feb 16;21:34. doi: 10.1186/s12915-023-01543-z

Author Correction: Activation function 1 of progesterone receptor is required for progesterone antagonism of oestrogen action in the uterus

Shi Hao Lee 1, Chew Leng Lim 1, Wei Shen 2, Samuel Ming Xuan Tan 1, Amanda Rui En Woo 1, Yeannie H Y Yap 1,3, Caitlyn Ang Su Sian 1, Wilson Wen Bin Goh 1, Wei-Ping Yu 4,5, Li Li 2,, Valerie C L Lin 1,
PMCID: PMC9933256  PMID: 36797738

Author Correction: BMC Biol 20, 222 (2022)

https://doi.org/10.1186/s12915-022-01410-3

The original article [1] contains two incorrect terms in the following sentence:

“We propose that the antioestrogenic effect of PGR at certain developmental stage (e.g. GD 2–3) is achieved by genomic upregulation of Esr1 and its coactivator Greb1 which in turn enhance the expression of other oestrogen target genes."

In the aforementioned sentence, 'upregulation' should instead be 'downregulation', and 'enhance' should instead be 'reduce', yielding the following, correct sentence:

“We propose that the antioestrogenic effect of PGR at certain developmental stage (e.g. GD 2–3) is achieved by genomic downregulation of Esr1 and its coactivator Greb1 which in turn reduce the expression of other oestrogen target genes."

Contributor Information

Li Li, Email: li.li@mail.hzau.edu.cn.

Valerie C. L. Lin, Email: cllin@ntu.edu.sg

Reference

  • 1.Lee SH, et al. Activation function 1 of progesterone receptor is required for progesterone antagonism of oestrogen action in the uterus. BMC Biol. 2022;20:222. doi: 10.1186/s12915-022-01410-3. [DOI] [PMC free article] [PubMed] [Google Scholar]

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