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. 2023 Feb 13;11:e14826. doi: 10.7717/peerj.14826

Figure 6. Bre inhibited NLRP3 activation and decreased podocyte injury in the renal tissues of DN mice.

Figure 6

(A) After being treated with Bre (30 mg/kg) for 4 weeks, the mice were euthanized, and renal tissues were collected to assess synaptopocin expression by IHC analysis. (B) qRT‐PCR analysis of α-SMA and podocin mRNA levels in the renal tissues of control mice, DN mice, and Bre-treated mice. (C) After being treated with Bre (30 mg/kg) for 4 weeks, the mice were euthanized, and renal tissues were collected to assess NLRP3 expression by IHC analysis. (D) qRT‐PCR analysis of IL-1β, IL-18, TNF-α, and IL-6 mRNA levels in the renal tissues of control mice, DN mice, and Bre-treated mice. **p < 0.01.