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[Preprint]. 2023 Feb 8:2023.02.06.23285545. [Version 1] doi: 10.1101/2023.02.06.23285545

Figure 1. Study overview.

Figure 1.

A. MS4A4A and TREM2 reside on the plasma membrane in microglia. Prior work demonstrates that rs1582763 is associated with elevated CSF sTREM2 and reduced AD risk (termed: protective) and rs6591561 is associated with reduced CSF sTREM2 and increased AD risk (termed: risk) B. Trans-eQTL analyses for rs1582763 and rs6591561 were performed using data derived from tissue samples representing three cortical areas in three independent cohorts (ROSMAP, frontal; Knight ADRC, parietal; Mayo, temporal). C. Trans-eQTL analyses were performed in human microglia clusters from single nuclei RNA-seq. D. Functional genomics were applied to define the impact of rs1582763 and rs6591561 on microglia function using iTF-microglia. E. Summary of major findings.