The effect of pulsed fields on the conduction system has not been well characterized. Selected lesions (n = 26) from four swine ventricles were submitted as part of a dosing study after bipolar, biphasic ablation using a multielectrode catheter (Faraflex, Farapulse Inc.) that delivers, microsecond pulses (2.2 kV)—four applications/site were applied. Histology after 4 weeks revealed a single image of viable Purkinje fibres (PjF), despite the ablation of adjacent cardiomyocytes as evidenced by fibrosis surrounding the PjF (Panel). The sparing of PjF seen, although a solitary finding, in this study may suggest a lower susceptibility than cardiomyocytes and requires further confirmatory studies.
This study was supported by a research grant from Farapulse Inc.
Contributor Information
Jacob S Koruth, Helmsely Electrophysiology Center, Department of Cardiology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1030, New York, NY 10029, USA.
Iwanari Kawamura, Helmsely Electrophysiology Center, Department of Cardiology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1030, New York, NY 10029, USA.
Vivek Y Reddy, Helmsely Electrophysiology Center, Department of Cardiology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1030, New York, NY 10029, USA.