Table 7.
Univariate analysis of overall survival in different MMR/MSI subgroups.
| Characteristic | d MMR (MSI-H) | p MMR (MSI-L/MS-S) | ||
|---|---|---|---|---|
| HR (95%CI) | P valuea | HR (95%CI) | P valuea | |
|
PD-L1 in primary tumours Positive vs negative |
0.23 (0.01–4.71) | 0.343 | 0.81 (0.39–1.67) | 0.590 |
|
PD-L1 in paired metastases Positive vs negative |
1.15 (0.07–18.58) | 0.919 | 0.65 (0.34–1.26) | 0.245 |
|
CD8 TILs in primary tumours High vs low |
0.10 (0.01–0.31) | 0.008 | 0.37 (0.15–0.92) | 0.026 |
|
CD8 TILs in paired metastases High vs low |
0.62 (0.04–10.68) | 0.728 | 0.47 (0.25–0.88) | 0.046 |
Note:
a
Univariate analysis of overall survival was performed using the log rank test. Bold indicates p < 0.05.