Table 4.

Results of molecule side effects caused by drug–drug interactions

Dataset	Method	Feature	ROC-AUC	PRC-AUC	AP@k
TWOSIDES	MLP (Rogers and Hahn, 2010)	Multimodal	0.826	0.812	0.735 (@50)
	Node2Vec (Grover and Leskovec, 2016)	Multimodal	0.907	0.889	0.830 (@50)
	SumGNN (Yu et al., 2021)	Multimodal	0.949	0.934	0.888 (@50)
	M2REMAP(base)	Chemical	0.901	0.912	0.897 (@50)
	M2REMAP	Chemical	0.986	0.978	0.993 (@50)
FAERS2021	M2REMAP(base)	Chemical	0.912	0.897	0.858 (@3)
	M2REMAP	Chemical	0.987	0.985	0.975 (@3)
SIDER-FAERS (cross-year)	M2REMAP(base)	Chemical	0.835	0.776	0.597 (@3)
	M2REMAP	Chemical	0.912	0.907	0.859 (@3)