Table 1.
Selected mass spectrometry based cytomatrix proteomics
| Structural proteins | Quantity | Enzymes and posttranslational protein modification | Quantity | Receptors, proto-oncogenes | Quantity | |
|---|---|---|---|---|---|---|
| 1 | Cytoskeleton-associated | 7 | Glycosyltransferase | 4 | Ras family | 15 |
| 2 | Golgi proteins | 88 | Oligosaccharyltransferase | 6 | Src family | 9 |
| 3 | ER/microtubule proteins, Receptors, Ca2+ homeostasis | 48 | Mannosyl-glycoprotein beta-1,2-N-acetylglucos-aminyl transferase | 7 | Tumor, metastasis associated proteins | 48 |
| 4 | Nuclear membrane | 22 | Mannosyltransferase | 15 | BRCA associated | 7 |
| 5 | Nucleoporins | 24 | Mannosyl-oligosaccharide glucosidase | 1 | Retinoblastoma | 9 |
| 6 | PM, membrane proteins | 166 | Mannosidase | 6 | Melanoma | 8 |
| 7 | AHNAK/desmosome | 3 | Acetylgalactosaminyl transferase | 7 | Abl Tyr-kinase | 5 |
| 8 | Transmembrane proteins | 61 | Dolichyl-saccharide-transferase | 6 | MYC associated | 7 |
| 9 | Junction proteins | 11 | O-linked GlcNAc transferase | 4 | MYB binding protein | 2 |
| 10 | Matrix proteins | 9 | Procollagen- 2-oxoGl-dioxygenase | 3 | Cbl proto-oncogene | 4 |
| 11 | Cell adhesion | 12 | Collagen b-(1-O) galactosyltransferase | 2 | Jun proto-oncogene | 2 |
| 12 | Actin, actin-binding, actin-like or related | 98 | Polysaccharide biosynthesis domain | 1 | DEK proto-oncogene | 1 |
| 13 | Tropomyosin/myosin | 29 | Phosphatidylinositol transfer protein | 5 | Growth arrest, arrestins | 6 |
| 14 | Keratins, type | 25 | Phosphatidylinositol glycan synthesis | 8 | Set proto-oncogene | 2 |
| 15 | Tubulins | 9 | α-2-HS-glycoprotein | 11 | Erb-b2 receptors | 6 |
| 16 | Profilins/cofilins | 4 | UDP-glucose glucosyl transferase | 1 | Growth factors, receptors | 29 |
| 17 | Catenin/cadherin | 5 | O-methyltransferase | 2 | G protein binding | 30 |
| 18 | Pleckstrin homology | 16 | Serine palmitoyl-transferase, long chain | 1 | Inositol-PPP-receptor | 3 |
| 19 | Stathmins | 2 | Palmitoyl-protein thioesterase | 5 | Cell division cycle, cyclins | 49 |
| 20 | Lectins | 7 | Membrane proteins, palmitoylated | 3 | Apoptosis signaling | 21 |
| 21 | Annexins | 10 | N- myristoyltransferase | 1 | p53 tumor suppressor | 4 |
| 22 | Spindle proteins | 13 | Farnesyl-PP-synthase | 1 | TNF receptors | 8 |
| 23 | Integrins | 13 | Farnesyl-PP farnesyltransferase | 3 | Calcium signaling | 19 |
| 24 | Adducin | 2 | Protein prenyltransferase | 1 | Hypoxia inducible family | 3 |
| 25 | Vinculin | 1 | Isoprenylcysteine methyltransferase | 1 | cAMP responsive element | 2 |