Skip to main content
. 2023 Feb 21;329(7):551–560. doi: 10.1001/jama.2023.0268

Figure 2. Risk of Alzheimer Disease by APOE Genotype Including APOE ε3[R145C] Subtypes.

Figure 2.

Alzheimer disease risk by APOE genotype compared with the ε3/ε3 reference group (ie, odds ratio for ε3/ε3 = 1) in (A) the stage 1 discovery composed of next-generation sequencing data from the Alzheimer Disease Sequencing Project data set and in (B) the stage 2 internal replication composed of imputed microarray data. Whiskers indicate 95% CIs. Orange data markers indicate the APOE genotype corresponding to the main novel result. See eTable 16 in Supplement 1 for underlying data.