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[Preprint]. 2023 Aug 25:2023.02.13.528384. Originally published 2023 Feb 14. [Version 2] doi: 10.1101/2023.02.13.528384

Fig. 7: Lrat-Mpc2−/− mice are protected from MASH exacerbated by thermoneutral housing.

Fig. 7:

At about 8 weeks of age, littermate wild-type (WT) and Lrat-Mpc2−/− (KO) mice were placed in thermoneutral housing (30°C) for 20 weeks. a, Terminal body weight, expressed as total mass and percent body weight gain from initiation of diet. b, Plasma levels of circulating transaminases ALT and AST collected at sacrifice. c, Liver weight measured at sacrifice, expressed as total mass and percent body weight. d, Analysis of fat mass determined by EchoMRI, represented as total mass and percent body weight. e, Hepatic gene expression measured by RT-qPCR and expressed relative to WT group. All data expressed as mean ± SEM (n=5–9/group). *p<0.05, **p<0.01.