Table 1.

Computation time comparison for high-dimensional mediation analysis methods

Method	n = 100, p = 200		n = 1,000, p = 2,000
	Mean	Interquartile Range	Mean	Interquartile Range
BSLMM	39.17s	(38.84s - 39.54s)	40.14m	(39.74m - 40.34m)
HDMA	1.40s	(1.37s - 1.40s)	29.76s	(29.55s - 29.92s)
HDMM	24.85s	(24.80s - 24.89s)	12.36m	(12.33m - 12.37m)
HILMA	24.42s	(24.13s - 24.63s)	40.85m	(38.22m - 40.65m)
HIMA	0.25s	(0.25s - 0.25s)	3.55s	(3.47s - 3.62s)
MEDFIX	0.61s	(0.60s - 0.61s)	7.33s	(7.22s - 7.42s)
PCMA	2.77s	(2.74s - 2.79s)	58.97s	(58.08s - 59.35s)
PLASSO	18.71m	(18.19m - 19.23m)	192.62m	(188.10m - 195.83m)
SPCMA	16.05m	(15.94m - 16.04m)	842.54m	(827.26m - 855.21m)

Methods were run 30 times each on a single core of an Intel(R) Xeon(R) Gold 6242R CPU @ 3.10GHz processor.