A7R |
Ala-Thr-Trp-Leu-Pro-Pro-Arg peptide |
AAT |
Anti-Angiogenic Therapy |
ADME |
administration, distribution, metabolism, excretion |
Ahx |
6-aminohexanoic acid |
Alloc |
Allyloxycarbonyl group |
Boc |
Tert-butyloxycarbonyl group |
BSA |
Bovine Serum Albumin |
CendR |
C-End-Rule |
Cys |
Cysteine |
DR7A |
DArg-DPro-DPro-DLeu-DTrp-DThr-DAla peptide |
Dab |
2,4-Diaminobutyric Acid |
DCM |
Dichloromethane |
DIC |
N,N’-Di(propan-2-yl)methanediimine |
DMF |
N,N-Dimethylformamide |
DOTA |
2,2′,2″,2″-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrayl) tetraacetic acid |
DOTA-tris(tBu)-NHS |
tri-tert-butyl 2,2′,2″-(10-(2-((2,5-dioxopyrrolidin-1-yl)oxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate |
ECL |
Enhanced chemiluminescence |
ELISA |
Enzyme-Linked Immunosorbent Assay |
ESI-MS |
Electrospray ionization mass spectrometry analyses |
Et3N |
Triethylamine |
Fmoc |
9-fluorenylmethoxycarbonyl group |
hArg |
Homoarginine |
HCl |
Hydrogen chloride |
His |
Histidine |
HOBt |
1H-1,2,3-Benzotriazol-1-ol |
HS |
Human serum |
IC50
|
Half maximal inhibitory concentration |
K4R |
Lys(hArg)-Dab-Pro-Arg peptidomimetic |
logP |
Decimal logarithm of partition coefficient |
m/z |
Mass-to-charge ratio |
NRP-1 |
Neuropilin-1 |
NS |
Negative control |
P |
Partition coefficient |
P |
Positive control |
Pbf |
Pentamethyl-2,3-dihydrobenzofuran-5-sulfonyl group |
PBS |
Phosphate-buffered saline |
PET |
Positron Emission Tomography |
PhOH |
Phenol |
PTFE |
Polytetrafluoroethylene membrane microfilter |
R/KXXR/K |
Amino acid sequence containing: R-Arginine, K-Lysine, X- any amino acid |
RP-HPLC |
Reverse-Phase High Pressure Liquid Chromatography |
RT
|
Retention time |
S |
Measured signal |
SD |
Standard Deviation |
SPPS |
Solid Phase Peptide Synthesis |
t1/2
|
Radionuclide half-life time |
tBu |
Tert-butyl group |
TFA |
Trifluoroacetic acid |
TIPS |
Tri(propan-2-yl)silane |
TRNT |
Targeted Radionuclide Therapy |
VEGF |
Vascular Endothelial Growth Factor |
VEGF-A165
|
Vascular Endothelial Growth Factor-A165
|
VEGFR-2 |
Vascular Endothelial Growth Factor Receptor 2 |
β+ Emax
|
Beta emitter with a maximum energy |
(bt)-VEGF-A165
|
Biotinylated VEGF-A165
|
(p,n) |
Proton-neutron nuclear reaction |