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. 2023 Feb 15;11(2):564. doi: 10.3390/biomedicines11020564
A7R Ala-Thr-Trp-Leu-Pro-Pro-Arg peptide
AAT Anti-Angiogenic Therapy
ADME administration, distribution, metabolism, excretion
Ahx 6-aminohexanoic acid
Alloc Allyloxycarbonyl group
Boc Tert-butyloxycarbonyl group
BSA Bovine Serum Albumin
CendR C-End-Rule
Cys Cysteine
DR7A DArg-DPro-DPro-DLeu-DTrp-DThr-DAla peptide
Dab 2,4-Diaminobutyric Acid
DCM Dichloromethane
DIC N,N’-Di(propan-2-yl)methanediimine
DMF N,N-Dimethylformamide
DOTA 2,2′,2″,2″-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrayl) tetraacetic acid
DOTA-tris(tBu)-NHS tri-tert-butyl 2,2′,2″-(10-(2-((2,5-dioxopyrrolidin-1-yl)oxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate
ECL Enhanced chemiluminescence
ELISA Enzyme-Linked Immunosorbent Assay
ESI-MS Electrospray ionization mass spectrometry analyses
Et3N Triethylamine
Fmoc 9-fluorenylmethoxycarbonyl group
hArg Homoarginine
HCl Hydrogen chloride
His Histidine
HOBt 1H-1,2,3-Benzotriazol-1-ol
HS Human serum
IC50 Half maximal inhibitory concentration
K4R Lys(hArg)-Dab-Pro-Arg peptidomimetic
logP Decimal logarithm of partition coefficient
m/z Mass-to-charge ratio
NRP-1 Neuropilin-1
NS Negative control
P Partition coefficient
P Positive control
Pbf Pentamethyl-2,3-dihydrobenzofuran-5-sulfonyl group
PBS Phosphate-buffered saline
PET Positron Emission Tomography
PhOH Phenol
PTFE Polytetrafluoroethylene membrane microfilter
R/KXXR/K Amino acid sequence containing: R-Arginine, K-Lysine, X- any amino acid
RP-HPLC Reverse-Phase High Pressure Liquid Chromatography
RT Retention time
S Measured signal
SD Standard Deviation
SPPS Solid Phase Peptide Synthesis
t1/2 Radionuclide half-life time
tBu Tert-butyl group
TFA Trifluoroacetic acid
TIPS Tri(propan-2-yl)silane
TRNT Targeted Radionuclide Therapy
VEGF Vascular Endothelial Growth Factor
VEGF-A165 Vascular Endothelial Growth Factor-A165
VEGFR-2 Vascular Endothelial Growth Factor Receptor 2
β+ Emax Beta emitter with a maximum energy
(bt)-VEGF-A165 Biotinylated VEGF-A165
(p,n) Proton-neutron nuclear reaction