Table 1.

Comparative analysis of Plasma D-dimer levels in SCD during the steady state and sickle crisis and in COVID-19 patients.

Subjects	Age/Reference	Plasma D-Dimer Levels		p-Value Compared to Controls
		Control	Disease State
Sickle Cell Disease	Adult [76]	HD (n = 35) 79 ± 25 ngh	Steady State SCD n = 25 (Samples = 28) 566 ± 739 ng/mL	p < 0.001
			SCD Painful Crisis n = 21 (Samples = 40) 1038 ± 1010 ng/mL	p < 0.001
	12–37 years [75]	SCD with pain crisis and normal chest X-ray (n episodes = 32) 584.2 µg/L (250–3119 µg/L)	SCD with pain crisis and abnormal chest X-ray (n episodes = 13) 2117.0 µg/L (250–9143 µg/L)	N/A
	Unventilated: 62.5 ± 8.4 Ventilated: 53.8 ± 9.3 [77]	Hospitalized COVID-19 patients did not require artificial ventilation (n = 18) 650 ± 175 ng/mL	Hospitalized COVID-19 patients requiring artificial ventilation (n = 11) 1250 ± 210 ng/mL	p < 0.05
COVID-19	65.57 ± 13 years [78]	COVID-19 patients without pulmonary embolism (n = 118) 1310 ng/mL (800–2335)	COVID-19 patients with pulmonary embolism (n = 44) 5364 ng/mL (2928–12,275)	p = 0.001