Figure 3.

Effect of cocaine on gastric motility in vitro. Addition of cocaine (10 µM) to antrum longitudinal (A,B) and circular (C,D) muscle-myenteric-plexus preparations (MMPs) significantly increased the motility index (amplitude multiplied the frequency). Addition of tetrodotoxin (TTX, 1 µM) 20 min prior to cocaine resulted in a comparable increase in the motility index in longitudinal and circular MMPs. N = five animals, nine MMPs for LM and CM. Data shown are the medians with the 25th and 75th quartiles as a box plot and the minima and maxima as a whisker plot, Wilcoxon test, * p < 0.05, ** p < 0.01.