Figure 4.

Effect of cocaine on intestinal epithelial secretion in vitro. Addition of cocaine (100 µM) to the serosal compartment of Ussing chambers significantly reduced EFS-evoked maximal increase (amplitude) in I_sc (A) and area under the curve (B) in guinea pig distal colonic mucosa–submucosa preparations compared to control tissues. Data shown are the medians with the 25th and 75th quartiles as a box plot and the minima and maxima as a whisker plot. N numbers (animals/preparations): four/eight for control, three/six for cocaine. Paired t-test (A) and Wilcoxon test (B), ** p < 0.01.