Figure 1. Stratification of neutrophil subtypes by DAMPs and mediators.

During sepsis, DAMPs (1^st circle) activate their receptors and signaling pathways to induce the production of inflammatory mediators (2^nd circle), which lead to neutrophil heterogeneity (3^rd circle). APN, antigen presenting neutrophils; RMN, reverse-migrated neutrophils; LDN, low-density neutrophils; OLFM4, olfactomedin 4; Siglec-F, sialic-acid-binding immunoglobulin-like lectin-F; NE, neutrophil elastase; IRF1, interferon regulatory factor 1.