Table 1.

Anti-Cancer effects of various types of quercetin nano-formulations based delivery systems.

S No.	Type of Nano Formulations/ Nanoparticles (Quercetin Based)	Type of Cancer	Study Model (Both In Vitro/In Vivo)	Particle Size (Nanometres (nm))	Effects	Concentration	References
1	PLGA nanoparticles	Cervical	HeLa	89.8 nm	↑ apoptosis ↑ Caspase-3 and 7	1, 10, 25 and 50 µM	[85]
2	PLGA nanoparticles	Breast	MCF-7	89.8 nm	↑ apoptosis frequency, ↑ Mitochondrial damage in Cancer Cells,	1, 10, 25 and 50 µM	[85]
3	PLGA nanoparticles	Breast	DMBA-induced mammary adenocarcinoma SD rats	89.8 nm	↓ average number of tumors and prolonged the tumor latency period	128 mg/kg	[85]
4	Poly (lactic-co-glycolic acid) nanoparticles	Glioma	C6	Qu1NP-215.2 nm, Qu2NP-282.3, Qu3NPs-584.5 nm	↓ cancer cell proliferation, ↑ SOD activity, ↑ GSH levels	1–100 μg/mL	[86]
5	Phenylboronic acid (PBA) conjugated Zinc oxide nanoparticles (PBA-zno)	Breast	MCF-7	40 nm	↑ apoptotic frequency, ↑ mitochondrial damage,	5–50 μg/ml	[87]
6	Polymeric (chitosan) nanoparticles	Lung	A549	<200 nm	↑ release, ↑ cytotoxicity to cancer cells	12.5, 25, 50, 75, 100, 150 and 200 μM	[88]
7	Polymeric (chitosan) nanoparticles	Breast	MDA MB 468	<200 nm	↑ release, ↑ cytotoxicity to cancer cells.	12.5, 25, 50, 75, 100, 150 and 200 μM	[88]
8	Polymeric micelles	Ovarian Multidrug resistant Breast	Skov-3 NCI/ADR MCF-7 and MDA-MB-231	24.83 to 45.88 nm	↓ cell viability, ↑ targeted drug release directly into the intracellular environment	6.25 to 100 μM	[89]
9	Gold-quercetin into poly (DL-lactide-co-glycolide) nanoparticles	Cervical	Male BALB/c nu/nu nude mice xeno-grafted with Caski cells	--	↓ tumor xenograft growth and development, ↑ KI-67, ↑ Bax, ↑ Bad, ↑ Cyto-c, ↑ ↓S6RP	--	[90]