Table 1.

Treatment Strategies for CDI.

	IDEA/SHEA	ACG	ESCMID	Current Review
Preferred Regimens for an Initial CDI Episode
Non-severe	Fidaxomicin	Fidaxomicin or vancomycin (metronidazole for low-risk only)	Fidaxomicin	Fidaxomicin or vancomycin (metronidazole for low-risk only)
Severe	Fidaxomicin	Fidaxomicin or vancomycin	Fidaxomicin or vancomycin	Fidaxomicin or vancomycin
Fulminant/complicated	High-dose vancomycin + IV metronidazole	High-dose vancomycin ± IV metronidazole	Vancomycin or fidaxomicin
Preferred Regimens for Recurrent CDI Episodes
First recurrence	Fidaxomicin	Fidaxomicin or tapered/pulsed vancomycin	First-line: Fidaxomicin or the addition of bezlotoxumab (tailored based on treatment regimen for the initial episode)	More data needed. Lowest recurrence rates with fidaxomicin
Second recurrence	Fidaxomicin, vancomycin tapered and pulsed regimen, vancomycin followed by rifaximin, FMT	Not specifically addressed	FMT or standard regimens and bezlotoxumab, if not used previously (tailored based on past treatment regimens)