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Antiproliferative activity (IC50, nM) of DOXO and CyD polymers in SK-N-SH and PMA stimulated SK-N-SH-PMA cells.
| Cell Line | DOXO | DOXO/ HALβCyD 8/1 |
DOXO/ HAHβCyD 8/1 |
DOXO/ HALβCyD 16/1 |
DOXO/ HAHβCyD 16/1 |
|---|---|---|---|---|---|
| SK-N-SH | 79.3 ± 23.5 | 83.5 ± 21.4 | 92.3 ± 13.4 | 22.1 ± 9.8 a | 24.6 ± 8.5 a |
| SK-N-SH-PMA | 82.7 ± 11.9 | 58.8 ± 13.4 b | 40.7 ± 13.8 a,c | 25.3 ± 8.7 a | 26.2 ± 3.9 a |
ap < 0.001 vs. DOXO, b p < 0.021 vs. DOXO, c p < 0.001 vs. cells SK-N-SH treated with DOXO/HAHβCyD 8/1.
