Table 3.
Correlation between IC50 of complexes DOXO/HALβCyD 8/1 and DOXO/HAHβCyD 8/1 and their DOXO uptake.
| Cell Line | MTT DOXO/ HALβCyD 8/1 (IC50, nM) |
MFI DOXO/ HALβCyD 8/1 a |
MTT DOXO/ HAHβCyD/ 8/1 (IC50, nM) |
MFI DOXO/ HAHβCyD 8/1 a |
|---|---|---|---|---|
| SK-N-SH | 83.5 ± 21.4 | 2.8 ± 1.6 | 92.3 ± 13.4 | 3.7 ± 0.7 |
| SK-N-SH-PMA | 58.8 ± 13.4 b | 4.2 ± 1.0 | 40.7 ± 13.8 c | 4.8 ± 2.0 |
a Values were normalized as absolute MFI calculated as MFI of treated cells—MFI of control cells. b p = 0.0536 vs. SK-N-SH cells, as evaluated by the Student’s t-test for independent means.c p = 0.0008 vs. SK-N-SH cells, as evaluated by the Student’s t-test for independent means.