Table 2.
Distribution of mercury exposure levels in the overall study population according to the GSTP1 A>G (rs1695) genotypes and alleles (Sawré Muybu indigenous territory, Pará State, Brazilian Amazon, 2019).
| GSTP1 (rs1695) A>G | Hg Levels (µg/g) | ||||
|---|---|---|---|---|---|
| ≤6.0 | >6.0 | p-Value 1 | Crude OR (95% IC) |
Adjusted OR 2 (95% IC) |
|
| (n = 32) | (n = 73) | ||||
| Genotypes | |||||
| AA | 11 (34.4) | 32 (44.4) | 0.001 | 1 | 1 |
| AG | 10 (31.2) | 36 (50.0) | 1.24 (0.47–3.30) | 1.23 (0.46–3.30) | |
| GG | 11 (34.4) | 4 (5.6) | 0.13 (0.03–0.48) | 0.13 (0.03–0.49) | |
| AA + GG | 21 (65.6) | 68 (94.4) | <0.001 | 1 | 1 |
| GG | 11 (34.4) | 4 (5.6) | 0.11 (0.03–0.39) | 0.12 (0.03–0.41) | |
| Alleles | |||||
| A | 32 (50.0) | 100 (69.4) | 0.007 | 1 | 1 |
| G | 32 (50.0) | 44 (30.6) | 0.44 (0.24–0.81) | 0.44 (0.24–0.81) | |
| GSTP1 (rs1695) A>G | Hg Levels (µg/g) | ||||
| ≤7.40 | >7.40 | p-value 1 |
Crude OR
(95% IC) |
Adjusted OR 2 (95% IC) | |
| (n = 53) | (n = 52) | ||||
| Genotypes | |||||
| AA | 21 (39.6) | 22 (43.1) | 0.05 | 1 | 1 |
| AG | 20 (37.7) | 26 (51.0) | 1.24 (0.54–2.86) | 1.24 (0.54–2.86) | |
| GG | 12 (22.6) | 3 (5.9) | 0.24 (0.06–0.97) | 0.24 (0.06–0.99) | |
| AA + GG | 41 (77.4) | 48 (94.1) | 0.02 | 1 | 1 |
| GG | 12 (22.6) | 3 (5.9) | 0.21 (0.06–0.81) | 0.22 (0.06–0.83) | |
| Alleles | |||||
| A | 62 (58.5) | 70 (68.6) | 0.13 | 1 | 1 |
| G | 44 (41.5) | 32 (31.4) | 0.64 (0.37–1.14) | 0.65 (0.37–1.14) | |
n = 105, missing information genotype for 1 individual and Hg levels from 2 individuals. 1 p-value obtained from the χ2 test (Pearson p-value) or Fisher’s exact test, when needed. 2 Odds ratio adjusted for age.