Viral titers of TOSV and RVFV in the presence of human, bovine, or camel IFITMs. Infection assays with TOSV (A) or RVFV (B) were performed in HEK293T cells expressing or lacking (pcDNA) the different IFITMs, as indicated. At 24 h post-infection, cell supernatants were collected, and viral titers were obtained by limiting-dilution assays in BSR cells. Each experiment was performed in triplicate and at least three times, independently. Bars indicate standard errors. Wilcoxon–Mann–Whitney statistical analyses were performed, and significance (compared to pcDNA data) is presented as follows: p < 0.05 (*), p < 0.01 (**) and p < 0.001 (***). hIFITM-1, human IFITM-1; hIFITM-2, human IFITM-2; hIFITM-3, human IFITM-3; bIFITM-a, bovine IFITM-a; bIFITM-b, bovine IFITM-b; cIFITM-a, camel IFITM-a; cIFITM-b, camel IFITM-b; cIFITM-c, camel IFITM-c.