Table 6.

Hazard ratios of cancer mortality by quartiles of urinary isoflavones and their metabolites.

	Quartile of Isoflavone Metabolites
HR (95%CI)	1Q	2Q		3Q		4Q		HR (95%CI)	p for Trend
Daidzein (ng/mL)	<16.6	16.6–48.8		48.8–195.0		≧195.0
model 1 (unadjusted)	1	1.31 (0.72, 2.37)	0.38	0.99 (0.53, 1.85)	0.97	1.22 (0.58, 2.55)	0.60	1.03 (0.82, 1.30)	0.56
model 2 (adjusted for age, race, and sex)	1	1.27 (0.69, 2.31)	0.44	0.88 (0.48, 1.61)	0.68	1.22 (0.60, 2.49)	0.59	1.02 (0.81, 1.29)	0.84
model 3 (multivariate)	1	1.41 (0.91, 2.19)	0.12	0.96 (0.53, 1.72)	0.89	1.38 (0.73, 2.62)	0.32	1.06 (0.87, 1.29)	0.78
ODMA (ng/mL)	<0.60	0.60–2.70		2.70–19.15		≧19.15
model 1 (unadjusted)	1	1.21 (0.68, 2.14)	0.51	0.90 (0.53, 1.52)	0.70	0.78 (0.46, 1.33)	0.36	0.90 (0.77, 1.06)	0.20
model 2 (adjusted for age, race, and sex)	1	0.93 (0.55, 1.58)	0.79	0.62 (0.38, 1.02)	0.06	0.63 (0.38, 1.05)	0.08	0.83 (0.71, 0.98)	0.03
model 3 (multivariate)	1	0.97 (0.49, 1.94)	0.94	0.63 (0.32, 1.22)	0.17	0.66 (0.31, 1.40)	0.27	0.84 (0.66, 1.06)	0.14
Equol (ng/mL)	<2.70	2.70–6.18		6.18–13.70		≧13.70
model 1 (unadjusted)	1	0.87 (0.47, 1.62)	0.67	1.04 (0.62, 1.76)	0.88	0.95 (0.54, 1.68)	0.87	1.00 (0.83, 1.22)	0.97
model 2 (adjusted for age, race, and sex)	1	0.85 (0.47, 1.54)	0.59	0.81 (0.50, 1.32)	0.40	0.83 (0.49, 1.40)	0.48	0.94 (0.79, 1.13)	0.53
model 3 (multivariate)	1	0.99 (0.54, 1.82)	0.97	0.88 (0.56, 1.38)	0.57	0.95 (0.60, 1.50)	0.82	0.97 (0.84, 1.13)	0.71
Genistein (ng/mL)	<8.35	8.35–24.90		24.90–88.60		≧88.60
model 1 (unadjusted)	1	1.12 (0.66, 1.90)	0.69	1.23 (0.75, 2.03)	0.41	1.14 (0.57, 2.29)	0.72	1.05 (0.86, 1.28)	0.65
model 2 (adjusted for age, race, and sex)	1	1.15 (0.68, 1.96)	0.60	1.13 (0.69, 1.86)	0.62	1.09 (0.53, 2.24)	0.82	1.02 (0.83, 1.26)	0.84
model 3 (multivariate)	1	1.20 (0.59, 2.40)	0.62	1.20 (0.65, 2.23)	0.55	1.18 (0.61, 2.30)	0.63	1.05 (0.87, 1.27)	0.63