Table 1.
Synthetic tailored magneto-fluorescent multimodal nanoparticles (NPs) and potential uses.
| Nanoparticles | Method | Targeting Ligand | Application | Ref. |
|---|---|---|---|---|
| Fe3O4/anti-IgG/GQD/BSA | Coupling | Human IgG | Urine renal disease | [83] |
| Ab (anti-aflatoxin B1)–CdS–Fe3O4 bioconjugates | Coupling | Aflatoxin B1 | Detection of aflatoxin B1 B1 in corn samples | [84] |
| Dox-loaded carbon dot (CD)–4-carboxyphenylboronic acid (CBBA)–MnFe2O4 NPs [DCCM] | Coupling | Sialic acid | HeLa cells | [85] |
| Iron oxide superparamagnetic NPs-PEG-Cypher5E/folic acid | Coupling | Folic acid | MR imaging and fluorescence imaging | [86] |
| Fe3O4(MNP)-Cds(QDs)-folic acid | Coupling | Folic acid | As a delivery agent and an in vitro imaging diagnostic agent | [87] |
| MTX-PEG-CS-IONPs-Cy5.5 | Coupling | Folic acid | Dual-model imaging and synergistically self-targeted cancer therapy | [88] |
| Fe3O4-dopamine hydrobromide (DPA)-PEG-FA/FITC NPs | Coupling | Folic acid | Targeted imaging of various tumors | [89] |
| Fe3O4-CdTe-humanized monoclonal antibody CC49 (hCC49 antibody) | Coupling | Tumor-associated glycoprotein-72 (TAG-72) | Cancer cell imaging | [90] |
| Fe3O4@mSiO2–triphenylphospine (TPP)/CD | Coupling | Mitochondria | Mitochondrial diseases | [91] |
| BRCAA1 antibody-FMNPs (Fe3O4-CdTe) | Encapsulation | BRCAA1 protein | In vivo dual-model imaging of gastric cancer | [92] |
| FMN (flavin mononucleotide)-coated ultrasmall superparamagnetic iron oxide (FLUSPIO) | Encapsulation | Riboflavin (Rf) | Prostate cancer xenografts | [93] |
| MNPs@OPE[oligo(p-phenylene ethynylene)]-PEG-FA | Folate receptor | Targeted magnetic resonance and two-photon optical imaging in vitro and in vivo | [94] | |
| Fe3O4@SiO2/RhBITC-anti-HER2 antibody NPs | Encapsulation | Human epidermal growth factor receptor 2 (HER2) | Discrimination of HER2-positive breast cancer cells | [95] |
| Fe3O4@SiO2(FITC)-FA/AICAR(5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside)/DOX | Encapsulation | Folate receptor | Inhibition of cancer cell growth | [96] |
| PTX/Fe3O4 NPs/CuInS2/ZnS QDs@biotin–PEG–PCD [abiotin–poly(ethylene glycol)–poly (curcumin-dithiodipropionic acid) copolymer] | Encapsulation | Biotin receptor | Treatment of multidrug-resistant breast cancer at the cellular level | [97] |
| Trastuzumab-conjugated Lipo[MNP@m-SiO2(FITC)] | Encapsulation | Her2/neu | In vitro fluorescence and MR imaging of Her2/neu-positive breast cancer | [98] |
| Fe3O4/CuInS2(CIS)@SiO2(Gd–DTPA)–RGD (arginine-glycine-aspartic acid) | Encapsulation | αVβ3 integrin | MR and fluorescence imaging of pancreatic cancer | [99] |