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. Author manuscript; available in PMC: 2023 Jun 9.
Published in final edited form as: Science. 2022 Dec 8;378(6624):1111–1118. doi: 10.1126/science.abq2787

Fig. 2. resR mutants showed faster recovery after drug exposure.

Fig. 2.

(A) MICs of resR mutants and wild type for 8 anti-TB drugs. INH: Isoniazid; RIF: Rifampicin; OFX: Ofloxacin; ETH: Ethionamide; EMB: Ethambutol; DCS: D-cycloserine; BDQ: Bedaquiline; LZD: Linezolid. Drug-resistance breakpoint is the drug concentration that defines clinical drug resistance. (B) Time-kill kinetics for 8 different drugs for resR mutant and wild-type Mtb strains. The concentration of each drug was 100-fold MIC. * symbol indicates statistical significance (P < 0.05) by unparied t test. (C) Representative images illustrating the post-antibiotic recovery dynamics of resR mutant (R95C) and wild-type (WT) Mtb strains.