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. 2023 Feb 27;47(7):1609–1616. doi: 10.1007/s00268-023-06957-y

Do Resident Coaching Programs Benefit their Coaches? Impact of a Professional Development Coaching Program on The Coaches

Andrea L Merrill 1,✉, Sharon L Stein 2,3, Jacqueline T Chu 4, Anuja L Sarode 2, Sophia K McKinley 5, Sareh Parangi 3,6, Karen Donelan 7, Kerri Palamara 4
PMCID: PMC9969939  PMID: 36847851

Abstract

Background

Coaching has been shown to decrease physician burnout; however, coachee outcomes have been the focus. We report the impact of coaching on women-identifying surgeons who participated as coaches in a 9-month virtual program.

Methods

A coaching program was implemented in the Association of Women Surgeons (AWS) to determine the effects of coaching on well-being and burnout from 2018 to 2020. AWS members volunteered and completed training in professional development coaching. Pre- and post-study measures were assessed, and bivariate analysis performed based on burnout and professional fulfillment score.

Results

Seventy-five coaches participated; 57 completed both pre- and post-study surveys. There were no significant changes in burnout or professional fulfillment including the Positive Emotion, Engagement, Relationship, Meaning, and Accomplishment scale, hardiness, self-valuation, coping, gratitude, or intolerance of uncertainty scores from baseline to post-survey. On bivariate analysis, hardiness was associated with lower burnout throughout the duration of the program. Coaches with lower burnout at the end of the program met with their coachee more frequently than coaches with higher burnout [mean (SD) 3.95(2.16) versus 2.35(2.13) p = 0.0099].

Discussion

Burnout and professional fulfillment demonstrated no change in women surgeons who participated as professional development coaches. Those with lower burnout and higher professional fulfillment at the end of the program were found to have higher hardiness, which may be worth future investigation.

Conclusions

Acquisition of coaching skills did not directly improve well-being in faculty who participated in a resident coaching program. Future studies would benefit from control groups and exploration of qualitative benefits of coaching.

Introduction

Burnout is highly prevalent among physicians, especially surgeons [1]. Recent studies have shown that half of the physicians in the US meet criteria for burnout [2] with rates ranging from 31 to 50% for surgery specialties, and even higher in women surgeons [1, 3–10]. Studies assessing burnout and well-being in women surgery residents and attendings have consistently found worse scores compared to their men counterparts [1, 5, 7–11].

Coaching has been proposed as a tool to decrease burnout among clinicians [12–15]. Recent data have demonstrated the successful implementation of coaching for residents with modest improvements in well-being parameters of professional fulfillment and burnout [13, 15–18]. However, these studies have analyzed the effects of coaching on the coachee, and there is a paucity of data on whether participating in a coaching program benefits the coaches [19, 20]. Additionally, little is known about how different levels of individual characteristics (e.g., hardiness, self-valuation, etc.) may influence well-being, burnout, and outcomes from coaching programs.

We report the impact of coaching on the well-being of practicing women surgeons (coaches) who underwent professional development coach training and participated in a 9-month virtual resident coaching program through the Association of Women Surgeons (AWS). We hypothesized that skills learned via this training would improve surgeon well-being and decreased burnout. Assessment used validated instruments that address well-being, including professional fulfillment, burnout, intolerance of uncertainty, and hardiness. We secondarily investigated whether there was any association between burnout and individual characteristics hypothesized to be correlated with burnout.

Methods

A coaching program was implemented through AWS to reduce burnout and improve well-being in women surgery residents from 2018 to 2020. AWS is a global professional surgical society whose mission is “to inspire, encourage, and enable women surgeons to realize their professional and personal goals.”[21] Concordant with its mission, AWS launched a program in which practicing surgeons volunteered for positive psychology coach training and subsequent pairing with women surgery trainees in a virtual coaching relationship. A secondary aim was to examine the effects on the coaches which is explored in this paper.

The research protocol, materials, and methods were approved by the Massachusetts General Brigham Institutional Review Board (Protocol #: 2017P00056) and funded through a grant to the Association of Women Surgeons Foundation by The Physicians Foundation. Methods and prior results of the clinical trial (ClinicalTrials.gov Identifier: NCT04883307) have been previously reported [17].

AWS members were recruited as unpaid volunteers via direct emails and social media to participate in the study as coaches (practicing surgeons) or coachees (residents). Sample size was based on the primary outcome in our previously published clinical trial in surgery residents [17]. Requirements for coaches included: AWS women-identifying member, currently in active surgical or surgical subspecialty practice in the United States (US) or Canada. Coachees were women-identifying surgery AWS resident members from the US and Canada.

All participants were required to complete informed consent, a baseline questionnaire including demographics, surgery specialty, and several validated instruments related to physician well-being. Instruments included the Stanford Professional Fulfillment Index (PFI); Positive Emotion, Engagement, Relationship, Meaning, and Accomplishment scale (PERMA); Intolerance of Uncertainty Scale (IUS); Gratitude Questionnaire (GR-6); Maintenance of Current Status (MOCS); and Hardiness-Resilience Scale (HRS/DRS-15) [22–25]. Region was determined using self-reported cities and states determined by the US Census Divisions [26]. Coaches completed a 3-h in-person coach training program at the AWS national meeting led by author, Kerri Palamara (KP), who is a subject matter expert (SME) in professional development coaching and has trained physician coaches across multiple specialties including surgery. Training consisted of didactic teaching combined with breakout discussions to practice coaching techniques and reflection exercises. Skills taught focused on active listening, asking powerful questions, and using positive psychology tools to facilitate goal setting and maximizing potential. During training, coaches completed several exercises they would then use to coach their coachee; with each exercise, coaches practiced as both coach and coachee and therefore had the opportunity to experience coaching themselves. Exercises focused on IUS, hardiness and resilience, gratitude, coping with stressors, using energy in ways that serve you, and work–life integration. Exercises were designed to emphasize these skills in everyday scenarios in their personal and professional lives. Unique aspects of the curriculum tailored to the study population included dealing with negative feedback, microaggressions, imposter phenomenon, and self-doubt.

Coaches were invited to participate in two optional, virtual 90-min refresher training sessions months 3 and 6 of the program. These virtual trainings were similar to the in-person sessions with virtual breakout rooms used to practice skills one-on-one. After the 9-month coaching period, all coaches were administered a similar follow-up questionnaire. Additional details regarding the coach training and program are published separately [13, 14, 16, 17]. Coaching materials were created by the SME in conjunction with the Institute of Coaching and surgeons who were involved with this project (ALM and SLS) to tailor specifically to surgeons. Coaches received a training manual developed by the SME and AWS with step-by-step guides for three structured coaching sessions with their coachees. Further details of the training have been previously published [18].

Upon completion of training, coaches were paired with 1–2 residents. Coach-coachee pairings were constructed based on divergent surgical special and geographic location to limit potential hierarchical relationships between the coach and coachee to foster psychological safety and minimize the possibility of developing a more traditional mentoring relationship. All coaching sessions occurred virtually over voice or video calls. Participants were encouraged to meet for at least three coaching sessions over the 9-month period but could meet more frequently if desired. Each meeting was 45–60 min in length, and specific exercises were given to review at each meeting.

Two cohorts of coaching are included in this study, 2018–2019 and 2019–2020. Of note, the COVID-19 pandemic occurred following the training of the second coaching cohort. As the coaching interactions and subsequent trainings were all held remotely, there was no change in protocol during the pandemic.

Study outcome measures of physician well-being included two primary outcome measures, the PFI and the PERMA scales. The PFI is composed of three subscales, on a 5-point Likert scale which includes professional fulfillment (5-point Likert scale [from not at all (0) to completely true (4)], 6 items); PFI subscale for burnout as combination of work exhaustion and interpersonal disengagement (5-point Likert scale ranging from not at all (0) to extremely (4)], 10 items, range 0–4). The PERMA overall score ranges from 0 to 75 based on 15 items on a 5-point frequency scale (1–5). Other measures included self-valuation (5-point Likert scale [ranging from never (0) to always (4)], 4 items, range 0–4)); IUS (5-point frequency [1–5], 12 items, range 0–60); Hardiness-resilience score (HRS/DRS-15, 4-point frequency (0–3), 15 items, range 0–45); Gratitude score (7-point frequency [1–7], 2 items from the GQ-6 scale, range 0–14); and Measurement of Current Status score (MOCS, 5-point frequency [1–5], 3 items from MOCS part A, range 0–15). PFI scores are calculated as the average of the scoring items while all other scores are summed across items [22–25, 27–29]. Measures were selected based on previously published research demonstrating the impact of coaching on well-being and associated parameters [13, 14, 30].

Participant demographics and characteristics were summarized for all who responded to the baseline survey and those who responded to both the baseline and follow-up surveys. To assess the difference in outcomes, our analysis was limited to participants who answered both baseline and follow-up surveys. Continuous variables are presented as mean (standard deviation (SD)), and categorical variables are presented as frequency (%). A paired t-test was used to compare the outcomes between pre- and post-period.

A bivariate analysis of burnout and PFI categories was performed to assess how certain characteristics (IUS, HRS/DRS-15, gratitude, self-valuation, coping, and PERMA) changed over time during the program and whether certain characteristics were associated with lower rates of burnout and higher professional fulfillment. To compare the outcomes between burnout and PFI categories, a two independent sample t-test was used. A two-sided with p-value < 0.05 was considered as statistically significant. All analyses were conducted using SAS 9.4 (SAS Institute, Cary, NC).

Results

From 2018 to 2019, we trained 75 attending surgeon coaches from 65 different surgery programs throughout the US and Canada. About 76% of coaches were from an academic affiliated program, and 42% were junior attendings in their first 5 years of practice. Demographics are detailed in Table 1.

Table 1.

Demographics of coaches

N (%)
N 75
Race, N (%)
Asian 10 (13.3%)
Black or African American 3 (4.0%)
White 30 (40.0%)
More than one race 1 (1.3%)
Other 3 (4.0%)
Ethnicity, N (%)
Hispanic 3 (4.0%)
Non-Hispanic 45 (60.0%)
Not answered 27 (36.0%)
Region, N (%)
Northeast 21 (28%)
Midwest 18 (24%)
South 25 (33.3%)
West 11 (14.7%)
Outside of the US (Canada) 0 (0%)
Specialty, N (%)
ACS/Trauma 13 (17.3%)
Non-general specialty 7 (9.3%)
Surgery subspecialty 47 (62.7%)
Cardiothoracic/vascular 5 (6.7%)
General 3 (4.0%)
Number of years in practice
0–5 33 (44.0%)
6–10 22 (29.3%)
11–15 11–15 (14.7%)
16 +  9 (12%)
Academic affiliated institution
Yes 57 (76%)
No 18 (24%)

Of 75 coaches, 46 were matched with two coachees, and 29 were matched with one coachee. Fifty-seven coaches completed both the pre-survey and post-survey and are included in the pre/post analysis. Response rate was lower in year 2 (22/30, 73.3%) than in year 1 (35/45, 77.8%). Data on meeting frequency were determined from coachee responses. About 12% of all respondents reported no coaching interaction. About 79.6% of coaching pairs (66/83) met at least once, 62.7% (52/83) met at least twice, and 49.4% (41/83) had three or more meetings.

About 24.5% (14/57) of coaches met criteria for burnout prior to the coaching program, and 35% (20/57) met criteria for burnout after the coaching program (p = 0.1573). There were no significant changes in our primary outcomes of well-being (PFI and PERMA) from baseline to post-survey. There were also no significant changes from baseline to post-study in measures of hardiness, self-valuation, coping, gratitude, or IUS (see Table 2).

Table 2.

Study outcomes in coaches before and after the study period

Scores Pre Post p-value
N Mean SD N Mean SD
Hardiness Communication 57 11.175 2.450 53 11.151 2.389 0.2224
Control 57 11.053 2.166 52 11.154 2.043 0.8423
Challenge 57 9.386 3.075 51 9.373 2.891 0.6677
Total 57 31.614 5.599 50 31.580 5.470 0.3216
PERMA Positive Emotion 57 11.070 1.761 54 11.111 1.766 0.5686
Engagement 57 11.702 1.463 55 11.691 1.914 0.6819
Relationships 56 12.000 1.945 55 12.200 2.004 0.8059
Meaning 57 12.614 1.868 55 12.782 2.323 0.9395
Accomplishment 57 11.702 1.658 55 12.127 1.963 0.2218
Total 56 59.018 6.751 54 59.778 8.004 0.9794
Intolerance of uncertainty Prospective 57 18.509 5.619 53 17.943 4.975 0.2596
Inhibitory 57 8.386 2.975 53 8.283 3.472 0.4278
Total 57 26.895 7.734 52 26.212 7.929 0.6892
WES 57 1.320 0.673 57 1.469 0.762 0.1457
ID 57 0.848 0.656 57 0.833 0.604 0.8672
SC 57 2.175 0.778 57 2.075 0.939 0.3598
Personal fulfillment 55 6.705 2.021 55 6.530 2.250 0.4138
Burnout 57 2.592 1.467 57 2.719 1.548 0.5325
Self-valuation 57 1.825 0.778 57 1.925 0.939 0.3598
Coping 57 8.316 2.037 55 7.909 2.390 0.0766
Gratitude 57 12.035 2.275 56 11.821 2.552 0.2538

To explore the potential relationships between individual characteristics and well-being outcomes, we performed bivariate analyses of study outcomes, with PERMA, hardiness, self-valuation, coping, gratitude, and intolerance of uncertainty. We stratified coaches by burnout status and by PFI score. Coaches with lower burnout at baseline (< 3.3) were more likely to have higher HRS/DRS-15 scores [mean (SD) 32.91(5.18) vs. 27.64(5.09) p = 0.0016] than those who had higher burnout (> 3.3) at baseline. This association between low levels of burnout and higher HRS/DRS-15 scores [mean (SD) 33.36(5.04) vs. 28.11(4.65) p = 0.0008] remained true after completion of the coaching program. There were no differences in PERMA, IUS, coping, self-valuation, and gratitude scores for those with high burnout versus low burnout prior to the program but after the program, coaches with lower burnout scores had significantly higher scores across all domains. Coaches at the end of the program with low burnout scores met with their coachee more frequently than the coaches with higher levels of burnout [mean (SD) 3.95(2.16) vs. 2.35(2.13) p = 0.0099] (see Table 3).

Table 3.

Bivariate analysis of study outcomes by burnout score in coaches

Scores Pre Post
Burnout < 3.3 (n = 43) Burnout >  = 3.3 (n = 14) p-value Burnout < 3.3 (n = 37) Burnout >  = 3.3 (n = 20) p-value
Mean SD Mean SD Mean SD Mean SD
Hardiness Communication 11.698 2.231 9.571 2.472 0.0039 12.000 2.128 9.500 2.007 0.0001
Control 11.302 2.099 10.286 2.268 0.1284 11.735 1.763 10.056 2.128 0.0037
Challenge 9.907 3.100 7.786 2.455 0.0236 9.706 2.866 8.706 2.91 0.2482
Total 32.907 5.177 27.643 5.093 0.0016 33.364 5.036 28.118 4.649 0.0008
PERMA Positive Emotion 11.233 1.757 10.571 1.742 0.2257 11.722 1.632 9.889 1.367 0.0001
Engagement 11.767 1.360 11.500 1.787 0.5573 11.972 1.764 11.158 2.115 0.1348
Relationships 12.209 1.910 11.308 1.974 0.1445 12.667 1.773 11.316 2.162 0.016
Meaning 12.791 1.780 12.071 2.093 0.2139 13.472 1.828 11.474 2.633 0.0017
Accomplishment 11.907 1.571 11.071 1.817 0.1019 12.667 1.852 11.105 1.792 0.004
Total 59.907 6.298 56.077 7.610 0.0727 62.500 6.893 54.333 7.404 0.0002
Intolerance of uncertainty Prospective 17.884 5.328 20.429 6.248 0.1426 17.167 4.748 19.588 5.185 0.0985
Inhibitory 8.000 2.645 9.571 3.674 0.086 7.343 2.828 10.111 3.939 0.0049
Total 25.884 7.145 30.000 8.884 0.0836 24.400 7.022 29.941 8.584 0.0165
Self-valuation 1.890 0.739 1.625 0.887 0.2728 2.095 1.033 1.613 0.646 0.0351
Coping 8.488 2.142 7.786 1.626 0.266 8.694 2.227 6.421 1.981 0.0005
Gratitude 11.884 2.710 11.615 2.022 0.7032 12.730 1.661 10.053 3.064 0.0017
Total times met with trainee 3.946 2.160 2.350 0.0099

When stratifying by PFI score, those surgeon coaches with a higher PFI score (> 7) before the program had significantly higher hardiness [mean (SD) 34.192(5.426) vs. 29.452(4.836) p = 0.001] and PERMA [mean (SD) 62.720(4.668) vs. 56.032(6.745) p < 0.0001] scores. After the program, those with higher PFI scores had greater HRS/DRS-15 scores [mean (SD) 34.440(4.691) vs. 28.720(4.695) p < 0.0001], PERMA [mean (SD) 64.8983(4.717) vs. 54.269(7.136) p < 0.0001], IUS, coping [mean (SD) 9.250(1.602) vs. 6.519(2.293) p =  < 0.0001], self-valuation [mean (SD) 2.317(1.011) vs. 1.491(0.622) p = 0.0005], and gratitude scores [mean (SD) 13.103(1.319) vs. 10.444(2.847) p =  < 0.0001] than those with lower PFI scores (see Table 4).

Table 4.

Bivariate analysis of study outcomes by PFI score in coaches

Scores Pre Post
PF < 7 (n = 31) PF >  = 7 (n = 26) p-value PF < 7 (n = 27) PF >  = 7 (n = 30) p-value
Mean SD Mean SD Mean SD Mean SD
Hardiness Communication 9.936 2.22 12.654 1.832  < .0001 9.692 2.205 12.556 1.601  < .0001
Control 10.581 1.996 11.615 2.264 0.0721 10.462 2.213 11.846 1.617 0.013
Challenge 8.936 2.670 9.923 3.475 0.2304 8.640 3.040 10.077 2.607 0.0757
Total 29.452 4.836 34.192 5.426 0.001 28.720 4.695 34.440 4.691  < .0001
PERMA Positive Emotion 10.323 1.869 11.962 1.113 0.0002 10.077 1.672 12.071 1.245  < .0001
Engagement 11.258 1.549 12.231 1.177 0.0111 11.000 1.819 12.357 1.789 0.0073
Relationships 11.613 1.978 12.480 1.829 0.0975 11.185 2.076 13.179 1.362 0.0001
Meaning 11.71 1.755 13.692 1.379  < .0001 11.333 2.270 14.177 1.307  < .0001
Accomplishment 11.129 1.450 12.385 1.602 0.0035 11.111 2.026 13.107 1.315  < .0001
Total 56.032 6.745 62.720 4.668  < .0001 54.269 7.136 64.893 4.717  < .0001
Intolerance of uncertainty Prospective 18.355 5.851 18.692 5.439 0.8237 19.000 4.983 17.000 4.861 0.1457
Inhibitory 9.226 3.222 7.385 2.334 0.0185 9.885 3.830 6.741 2.229 0.0008
Total 27.581 8.398 26.080 6.934 0.4697 29.040 8.438 23.593 6.541 0.0118
Self-valuation 1.758 0.666 1.904 0.900 0.4858 1.491 0.622 2.317 1.011 0.0005
Coping 7.871 2.125 8.846 1.826 0.0714 6.519 2.293 9.250 1.602  < .0001
Gratitude 11.400 2.848 12.308 2.112 0.1779 10.444 2.847 13.103 1.319  < .0001
Total times met with trainee 3.482 2.119 3.300 0.7657

Discussion

This paper analyzes the effects of positive psychology coaching on the faculty physician coaches with respect to burnout and well-being. We found no significant improvements in PFI, burnout, or PERMA scores after the completion of the program for coaches. There may be several reasons for this including low sample size, lack of control group, survey response rate, as well as other organizational/individual factors. It is notable that we did not see any significant worsening of these scores during the study, as our program spanned the start of the COVID-19 pandemic. There are much data on increased physician burnout rates during the COVID-19 pandemic, particularly female physicians [31–33]. The fact that well-being measures were stable may demonstrate the nurturing effects of the program on coaches. In comparing cohorts from year 1 (pre-COVID-19) and year 2 (which spanned the pandemic), there were no significant differences in mean burnout score before or after the program. The coaching program potentially may have supported these female surgeons during this uniquely stressful time by training them in personal reflection, goal setting, coping, communication, tolerating uncertainty, and self-valuation.

Overall, we observed low levels of burnout throughout the study, in contrast with prior studies of women surgeons [17, 34, 35]. Mete et al. reported that 46% of female surgeons in their study met criteria for burnout compared to 33% in male surgeons [10] while Dyrbye et al. reported a 43.3% burnout rate compared to 39.0% in men [8]. In our study, only 22.8% met criteria for burnout at baseline and 35% at the end of the program. This could be explained by self-selection by coaches, as it might be hypothesized that those with higher burnout might be less likely to volunteer as a coach. In the future, it would be valuable to ask surgeons about their motivation in volunteering for the program. Interestingly, we did find that lower burnout was associated with more frequent coaching sessions, suggesting perhaps that those with lower burnout were more available and engaged in coaching than those with higher burnout, or perhaps that coaching (helping others) was protective from burnout. Additionally, being part of this project created new connections among female surgeons which could have contributed to decreased burnout.

It is worth noting that certain individual characteristics were different in those with or without burnout and that these varied from baseline to post-study survey. Specifically, those with higher hardiness scores were less likely to be burned out, suggesting a possible protective effect of hardiness. Hardiness has been defined as the ability to adapt under stressful conditions while maintaining emotional stability [36] whereas grit has been defined as an individual’s passion and dedication to achieve a long-term goal [37]. A prior study by Betchen et al. found no association between grit and gender [11]. Additionally, based on the definition of grit, one might not expect that to change with coaching, whereas one might expect hardiness to improve with coaching (which was found in our trainee study) [17]. Therefore, we chose to use the measure of hardiness by the HRS/DRS-15 score for this study.

After completion of the coaching program, we did see significantly higher levels of all individual characteristics hypothesized to be correlated with burnout (e.g., hardiness, IUS, coping, and gratitude) in those who were not burned out. This may suggest that some of these characteristics may be modifiable through training and acquiring new skills, such as coaching skills. Research has suggested that certain characteristics are innate, present in us from birth, while others are acquired throughout our lives through experience[38]. Hypothesized innate characteristics include tolerance of uncertainty, resilience, and gratitude [39–41]. In contrast, professional fulfillment, burnout, and self-valuation are viewed as acquired skills. All of these skills, whether innate or acquired, can be mutable and liable to change with certain skill development [27, 42, 43]. Our results demonstrating the correlation of hardiness and burnout suggest that we might target improving these skills and personality characteristics in future coaching programs and research.

There are several limitations to our study. Our small sample size can limit results and fail to detect key differences, particularly without a control group. As the study was powered to identify changes in coachees, this may suggest a type 2 error. The response rate, although good comparatively, limits the ability to evaluate whether those who did not complete the surveys had different responses and potentially benefited less from the program, further altering results. The low burnout rates in our study may limit generalizability of the study. More importantly, this coaching program did not occur in a vacuum. Other life factors, including the initial stages of the COVID pandemic, could have influenced the burnout and well-being scores beyond just this program. Additionally, coaching is just one component of a burnout prevention toolkit. Lastly, we only studied women surgeons in the present study. It is possible that we would have found different outcomes in more inclusive populations. KP has been working to expand this program to other societies including the American Pediatric Surgical Association and the American College of Physicians, as well as multispecialty implementation within graduate medical education programs nationally [44, 45].

Conclusion

In this study which trained women surgeons in positive psychology coaching techniques for a 9-month resident coaching program, burnout and well-being scores were stable over time among coaches. While burnout and professional fulfillment outcomes did not change as a result of the program, we did find an association in certain characteristics associated with well-being in those with low burnout scores at the end of the program.

This paper suggests several possible avenues for future study. Most of our analysis was quantitative using previously validated tools to measure burnout and well-being. A qualitative study may reveal more insight over a purely quantitative analysis. Additionally, perhaps, eliminating burnout should not be the ultimate outcome and goal of these studies. Rather, we should focus on targeting individual characteristics that can improve coping skills and experiences in domains of physicians’ personal and professional lives. Expanding this program to all surgeons in the future may give more insight into the impact of this program on coaches.

Acknowledgements

Only women-identifying coaches were studied as this was conducted through the Association of Women Surgeons and because we specifically wanted to address the higher rates of burnout found in women surgeons. We plan to expand to other genders in the future.

Funding

This study was supported by a Grant from the Physicians Foundation in the amount of $100,000. Grant monies paid for the statistical analysis (Sarode and Donelan), training (Palamara), and curriculum development (Palamara).

Declarations

Conflict of interest

Dr. Palamara was paid a consulting fee for coach training and curriculum development. No other disclosures are reported.

Ethical approval

The study was approved by the Massachusetts General Hospital IRB.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Footnotes

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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