Letter to the Editor Regarding “The Effect of COVID-19 Vaccines on Stroke Outcomes: A Single-Center Study”

We would like to share ideas on the publication “The Effect of COVID-19 Vaccines on Stroke Outcomes: A Single-Center Study.¹” El Naamani et al. contrasted the results of stroke patients who had received the COVID-19 vaccine and those who had not.¹ Although immunization did not significantly affect stroke patient outcomes at follow-up, El Naamani et al. reported that vaccination was linked to lower rates of morbidity and mortality among stroke patients upon discharge during the pandemic.¹

We both believe that those with underlying medical conditions may respond to the vaccine differently from people in good health. To get at the correct interpretation, a number of factors must be taken into account. A genuine bad reaction was one of the possible confounding factors that might have had an impact on the results of the initial dose. Examples include the COVID-19 strain, the delivery mechanism, the setting, and the recipient's co-morbidity prior to vaccination. The absence of clinical symptoms and asymptomatic COVID-19 may be related.² If neither the preceding symptoms nor the current symptoms are present, a COVID-19 must be ruled out. The chance of cross-contamination with an unidentified SARS-Co-V2 infection cannot be completely ruled out. It is impossible to completely rule out an unidentified SARS-Co-V2 infection. It has been investigated and established that inherited genetic variation affects vaccine recipients' immunological reactions.³ More empirical clinical research should be conducted to determine whether or not the conclusions of findings from the current work are supported.