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[Preprint]. 2024 Feb 27:2023.02.23.529684. Originally published 2023 Feb 23. [Version 2] doi: 10.1101/2023.02.23.529684

Single-neuron spiking variability in hippocampus dynamically tracks sensory content during memory formation in humans

Leonhard Waschke, Fabian Kamp, Evi van den Elzen, Suresh Krishna, Ulman Lindenberger, Ueli Rutishauser, Douglas D Garrett
PMCID: PMC9980052  PMID: 36865320

Abstract

During memory formation, the hippocampus is presumed to represent the content of stimuli, but how it does so is unknown. Using computational modelling and human single-neuron recordings, we show that the more precisely hippocampal spiking variability tracks the composite features of each individual stimulus, the better those stimuli are later remembered. We propose that moment-to-moment spiking variability may provide a new window into how the hippocampus constructs memories from the building blocks of our sensory world.

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