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. 2023 Feb 26;14(1):2180938. doi: 10.1080/21505594.2023.2180938

Figure 5.

Figure 5.

Fructose potentiates ampicillin to kill AR-GBS. (a) Percent survival of AR-GBS in the presence of the indicated metabolites plus Amp. (b) Percent survival of AR-GBS in the indicated concentrations of fructose plus 1/2 MIC Amp. (c) Percent survival of AR-GBS in the indicated concentrations of Amp plus 20 mM fructose. (d) Percent survival of AR-GBS in 20 mm fructose plus 1/2 MIC Amp at the indicated incubation periods. (e) Percent survival of clinical isolated MRSA8, MRSA18, S2-lac and TMM2 in the indicated concentrations of Amp plus 20 mM fructose. (f, g) Killing effect of the indicated concentrations of Amp plus 20 mM fructose in treating persisters and bacterial biofilms. (h) Percent survival of zebrafish infected with AR-GBS in the presence or absence of Amp, fructose or both. Results are displayed as mean ± standard errors of the means (SEM) (N ≥ 3 technical replicates per sample), and statistically significant differences are identified by t-test. *, p < 0.05, **, p < 0.01. Each experiment was repeated independently at least three times.