Figure 4. The metamorphic fates of the larval mushroom body output neurons (MBONs).
(A) The fates of the larval MBONs that innervate the calyx and the 10 compartments of the larval MB. For MBONs that remain within the MB after metamorphosis, the arrows show the relationship of their larval compartment to the one that they innervate in the adult MB. The remaining MBONs trans-differentiate (T) to supply non-MB circuits in the adult, or their fate is unknown (?). Compartment designations as in Figure 2. Transmitters: green: acetylcholine; blue: glutamate; red: GABA; gray: unknown; checkered versions are presumed transmitters based on Li et al., 2020. (B) Images comparing the larval and adult forms of the MBONs that persist through metamorphosis. The images of larval cells from Saumweber et al., 2018 Nature Comm. 9: 1104. Adult names based on Aso et al., 2014, Li et al., 2020, or this study.
Figure 4—figure supplement 1. Confocal projections showing the terminal, adult identity of larval mushroom body output neurons (MBONs) that undergo trans-differentiation at metamorphosis.
