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. 2022 Dec 8;92(4):680–694. doi: 10.1227/neu.0000000000002275

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Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Congress of Neurological Surgeons.

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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FIGURE 1. — Peer-reviewed publications in psychedelic science from 1990 through June 2022: The four graphs show over the last 3 decades an initial slow then rapid rise in articles focused on clinical applications of all psychedelics, MDMA, psilocybin, and LSD. Publications are shaded to distinguish between CT results or MA and R (Methodology: PubMed was searched using the terms: psychedelic, clinical trial, LSD, 3,4-MDMA, and psilocybin for both human and animal investigations.). CT, clinical trial; LSD, lysergic acid diethylamide; MA, meta-analyses; MDMA, 3,4-methylenedioxymethamphetamine; R, reviews.