Table 3.
Diagnostics for differentiation of de-novo lymphoid BP and Ph-positive ALL.
| Investigation | de-novo lymphoid BP | Ph-positive ALL | Comment |
|---|---|---|---|
| Morphology | = | = | |
| Flow cytometry | = | = | |
| Cytogenetics/FISH | = | = | Cytogenetic or FISH positivity at the end of induction therapy as an indicator for CML-BP |
| BCR::ABL1 detection via interphase FISH on neutrophils | + | − | performed after major blast reduction |
| Comparison MRD-level (IgG, TCR -rearrangement or flow cytometry)/ BCR::ABL1 transcript level | ↓/~ | ↓/↓ | performed after the end of induction therapy |
= indifferent, + positive result, - negative result, ↓ declining, ~ divergent reduction.