Table 3.
SA polygenic prediction
| Model | OR (95% CI) | P | Nagelkerke R2 (%) | Variance explained (%) |
|---|---|---|---|---|
| SAprs | 1.15 (1.08–1.21) | 5.6e−06 | 0.4 | 0.45 |
| SAprs (adjusting for BMI) | 1.09 (1.03–1.16) | 4.2e−03 | 0.17 | 0.45 |
| SAmtagSnoringprs | 1.21 (1.14–1.28) | 3.9e−10 | 0.77 | 0.87 |
| SAmtagSnoringprs (adjusting for BMI) | 1.14 (1.07–1.21) | 2.4e−05 | 0.37 | 0.87 |
Results of PRS derived using our GWAS (leaving out the AGDS cohort) predicting sleep apnea in the AGDS sample with and without accounting for BMI measures in AGDS. Note significant prediction even after adjusting for BMI measures. Abbreviations: SAprs, sleep apnea meta-analysis; SAmtagSnoring, sleep apnea plus snoring MTAG.