Abstract.
Significance
The scanning fiber endoscope (SFE), an ultrasmall optical imaging device with a large field-of-view (FOV) for having a clear forward view into the interior of blood vessels, has great potential in the cardiovascular disease diagnosis and surgery assistance, which is one of the key applications for short-wave infrared biomedical imaging. The state-of-the-art SFE system uses a miniaturized refractive spherical lens doublet for beam projection. A metalens is a promising alternative that can be made much thinner and has fewer off-axis aberrations than its refractive counterpart.
Aim
We demonstrate a transmissive metalens working at 1310 nm for a forward viewing endoscope to achieve a shorter device length and better resolution at large field angles.
Approach
We optimize the metalens of the SFE system using Zemax, fabricate it using e-beam lithography, characterize its optical performances, and compare them with the simulations.
Results
The SFE system has a resolution of at the center of field (imaging distance 15 mm), an FOV of , and a depth-of-focus of , which are comparable with a state-of-the-art refractive lens SFE. The use of the metalens reduces the length of the optical track from 1.2 to 0.86 mm. The resolution of our metalens-based SFE drops by less than a factor of 2 at the edge of the FOV, whereas the refractive lens counterpart has a times resolution degradation.
Conclusions
These results show the promise of integrating a metalens into an endoscope for device minimization and optical performance improvement.
Keywords: endoscope, scanning fiber, metalens, large field-of-view, ultrasmall optics, infrared angioscope
1. Introduction
In the diagnosis of diseases and surgery in the cardiovascular system, it is essential to have a clear view into the interior of blood vessels. An endoscope with an extremely small diameter and short rigid tip length can provide a viable solution. To that end, scanning fiber endoscopes (SFEs) have already been demonstrated as one of the smallest forward viewing endoscopes due to their single point scanning based optical sensing mechanism.1,2 Alternative techniques include imaging through a lens on a coherent fiber bundle (CFB) array3,4 or a camera sensor chip-on-tip,5 which are difficult to miniaturize while maintaining large field-of-view (FOV) and high resolution. SFEs also feature a large depth-of-focus (DOF) (>10 mm), have a larger FOV, and more pixels than CFB arrays and camera sensors chip-on-tip.6
The short-wave infrared (SWIR) wavelength regime is of particular interest for the surgery-assisting endoscopy used inside blood vessels, as they are the shortest wavelength ranges to ensure both reduced scattering and low water absorption. This enables an infrared (IR) endoscope design7 to see through blood without requiring any additional clearing. In fact, an SWIR SFE at 1310 nm has already been reported:8 here a compound refractive spherical lens is used to project the beam emitted from a scanning single mode fiber to a large range of angles ( to 35 deg relative to the optical axis). The size of this optical element is one of the major limitation factors for further miniaturization of the rigid tip length of the SFE system. In addition, the spherical lens also suffers from large aberration when the beam is projected to off-axis angles.
Metaoptics has recently emerged as a promising alternative to drastically miniaturize optical elements.9 Metaoptics consists of quasi-periodic arrays of subwavelength scatterers, each of which can be designed to impart a desired phase, amplitude, polarization, and spectral control of light. The ability to engineer any phase-mask with subwavelength resolution makes metaoptics an excellent candidate to create ultrathin freeform optics.10 Metaoptical lenses, commonly known as metalenses, are extremely thin (thickness approaching for SWIR), and can be fabricated to have very small area. By intelligently designing the phase-mask, metaoptics can correct for aberrations at large off-axis angles, without using multiple optical components.11 This ability of metaoptics has already inspired several works on metaoptical endoscopy.12–14 Here, we report an SFE system with a metalens working at 1310 nm to achieve comparable resolution, FOV, and DOF as the state-of-the-art while minimizing the rigid tip-length and reducing the aberration at large off-axis angles. Figure 1 shows the schematic of our SFE system. This imaging system has a full FOV of 70 deg and a DOF of (in this range, the resolution drops by less than a factor of 2). The replacement of the refractive compound lens with a single metalens reduces the length of the optical track of the SFE from 1.2 to 0.86 mm. The spatial resolution at the center of the field is at an illumination distance of 15 mm, which corresponds to an angular resolution of 0.53 deg. This resolution drops by less than a factor of 2 at the edge of the FOV.
2. Design and Fabrication of the Metalens
2.1. Design of the Metalens
The purpose of the metalens in our SFE system is to project the beam emitted from the tip of the scanning fiber to the illumination plane. Specifically, the beam incident at different positions of the metalens is guided to different angles. The SFE should have a wide range of imaging distance, wherein the projected beam maintains a small diameter. Therefore, the projected beam should be collimated. This functionality can be realized by a single-layer optical component, which can be approximated by a hyperboloid focusing lens. This lens creates an image of the fiber tip at infinite distance when the tip is at the focal plane of the lens. Therefore, we assume the initial phase profile of the metalens as
(1) |
where is the radius from the center of the lens, is the wavelength (1310 nm), is the focal length of the lens, and is the distance between the fiber tip and the metalens, .
The phase profile of the metalens is then optimized using the ray-tracing simulator Zemax Optical Studio. The metalens is represented by a binary2 phase mask whose phase profile is expressed as
(2) |
where is the number of order, and are the corresponding coefficients that we optimize. To ensure centrosymmetry, only even-order exponents are considered. We set , as the first three terms turn out to be sufficient for our optimization. We use (i.e., ) as the starting point for optimization.
Figure 2(a) shows the cross section of our SFE system in the ray-tracing simulation. The trajectory of the fiber tip during scanning is represented by the object plane, whose geometry is predicted by a theoretical model.15 The distance between the fiber and lens , the radius of the object plane (which represents the range of motion of the fiber), and the numerical aperture (NA) of the aperture (which is the NA of the fiber) are important design parameters that determine the FOV, DOF, and resolution of the SFE system. and determine the half-FOV by . A smaller is desired not only because it reduces the length of the optical track of the SFE system but also requires a smaller fiber scanning range to achieve a certain half-FOV. However, the width of the beam on the metalens () also decreases with , leading to a larger diverging angle () of the projected beam, which degrades the DOF and resolution of the SFE system. The fiber we use has an NA of 0.18. We set to ensure a relatively short optical track length and acceptable projected beam diverging angle, and to get a half FOV of 35 deg. To optimize the SFE performance, the coefficients , and are adjusted to minimize the spread of the ray at . Specifically, we choose seven uniformly spaced points along the -axis in the object plane, and minimize the average radius of the resulting seven spots in the image plane. The point spread function (PSF) is the intensity distribution of the beam projected by the metalens, which determines the resolution of the SFE system. We used the Huygens method in Zemax to calculate the PSF.
Compared with a state-of-the-art SFE system with a refractive spherical lens doublet [Fig. 2(b)], our SFE system with the metalens shows the same FOV of 70 deg, a comparable full-width-at-half-maximum (FWHM) of the PSF at the center of the field [Fig. 2(c)], and a much smaller root-mean-square (rms) radius of the spot diagram as well as a higher Strehl ratio at the projection angle [Fig. 2(d)]. This means that our metalens can reduce the spherical aberration at large projection angles. The use of the metalens also reduces the optical track length in the SFE from 1.2 to 0.86 mm. This length can be further reduced to using a thinner substrate (, which is mechanically strong enough to withstand the fabrication process and retain flatness in SFE setting) and a smaller between the fiber and the lens. As shown in Fig. 2(c), reducing increases the beam diverging angle, which indicates a degraded resolution and DOF. This can be mitigated by increasing the NA, at the cost of a larger aberration at large beam projection angles.
2.2. Meta-Atom Pattern Design
The phase profile of the metalens obtained from the ray-tracing simulation is wrapped and further discretized into 12 levels, as shown in Fig. 3(a). These phase levels are realized by a crystalline silicon (cSi) on sapphire () metaoptics, in which the subwavelength nanoposts with different sizes act as local scatterer to impose the desired phase response on the incident light. We use rigorous-coupled wave analysis (RCWA)16 to theoretically calculate the phase and transmission response versus the scatterer size, as shown in Fig. 3(b). This allows us to pick the right scatterer size at specific locations and thus construct the metalens.
2.3. Metalens Fabrication
The metalens is fabricated using an electron beam lithography (EBL) process. A resist (ZEP-520A) on a -thick crystalline Si-on-sapphire substrate is patterned by EBL, then a -thick hard mask is created by electron beam-assisted evaporation followed by resist ( thick) lift-off in -methyl-2-pyrrolidone at overnight. Subsequently, the crystalline-Si layer is etched by a fluorine-based reactive ion process. The scanning electron microscopy (SEM) images of the fabricated metalens are shown in Figs. 3(c) and 3(d).
3. Characterization of the Metalens
3.1. Experimental Setup
The DOF and resolution of our SFE system are determined by the longitudinal (in the plane) and transverse (in the plane, also the illumination plane) intensity distribution of the beam projected by the metalens. Figure 4(a) shows the schematic of the setup for measuring these beam intensity distributions. A customized fiber scanner is built.8,15 The parameters of this fiber scanner are summarized in Table 1. In our SFE, the metalens projects the beam emitted from the tip of the scanning fiber to different angles within a total FOV of 70 deg. A movable IR microscope consisting of an objective (Mitutoyo Plan Apo NIR , , ), a tube lens (Thorlabs AC254-075-B-ML, ), and an IR sensor (WiDy SenS S320 V-ST) is placed in front of the metalens along the optical axis to characterize the beam on the focal plane of the microscope. This microscope is mounted on a three-dimensional translation stage, which can be moved either along the optical axis (in -direction) or perpendicular to it (in the plane). By moving the microscope along the -direction, the beam transverse intensity distribution at different illumination distances can be measured to construct the longitudinal distribution. By moving the microscope in the plane, the beam intensity distribution at different projection angles can be measured. At beam projection angles relative to the optical axis, the objective does not have a large enough NA to capture the light. Therefore, a frosted film is put at the focal plane of the microscope to scatter the beam, and the scattered beam is collected with the microscope.
Table 1.
Component | Parameters |
---|---|
Scanner housing | 3.8-mm inner diameter (ID), 9.4-mm outer diameter (OD) |
Single-mode fiber | 0.18 NA, mode-field diameter, cladding diameter |
coating diameter, 5.5-mm free-standing length | |
Piezo tube | 1.9-mm ID, 2.48-mm OD, 11.6-mm length |
3.2. Longitudinal Intensity Distribution of the Beam
We first construct the longitudinal intensity distribution (in the plane) of the beam projected by the metalens at 0-deg projection angle (i.e., neutral position of the fiber) by translating the microscope along the optical axis and take images of the beam at different . Figure 4(b) shows the image of the beam, taken at . The one-dimensional (1D) intensity distribution along the -axis (the red dashed line) is plotted across the image and further fitted by a Gaussian distribution function. From further measurements of the 1D distributions along the -axis at different planes in the range to 15 mm, we construct the longitudinal intensity distribution (in the plane), shown in Fig. 4(c). Importantly, this directly indicates that the beam diverges only slightly over a long distance of 15 mm. Further 1D intensity distributions for different -distances are plotted in Fig. 4(d), showing how the beam shape is maintained over to 15 mm while slightly broadening. To further characterize this system, we use an analytical model based on Gaussian beam propagation, summarized in Fig. 4(e), where the FWHM of the 1D intensity distribution as a function of can be well fitted using
(3) |
By fitting, we estimate the beam waist at position with waist width , which corresponds to an FWHM of , whereas further along the optical axis at , the beam enlarges to . The FWHM of the 1D intensity distribution of the projected beam increases by less than a factor of 2 when increases from 0 to 15 mm. Therefore, we define the DOF of our SFE system to be 15 mm. We demonstrate that the beam projected by the metalens has a longitudinal intensity distribution close to a Gaussian beam whose beam waist is at the position of the metalens, which yields the minimal diverging angle for a certain beam width. This ensures a large DOF of 15 mm in our SFE system. The measured beam longitudinal distribution slightly deviates from the simulation results calculated in Zemax ray-tracing simulation using Huygens method [black dashed line in Fig. 4(e)]. We attribute this to the fact that the actual beam from the fiber deviates from our model of a point source.
3.3. Scanning Beam FWHM at Various Projection Angles in the Illumination Plane
We characterize the spatial resolution of the SFE system at various angles in the illumination plane by measuring the FWHM of the 1D transverse intensity distribution of the scanning beam. This 1D distribution of the beam can be measured by taking the image of a stable trajectory of the scanning beam with an exposure time exceeding 10× the scanning periodicity of the fiber.
We actuate the fiber scanner at a resonance frequency of 2187 Hz with a stable sinusoidal input signal to scan along an elliptical trajectory. This causes the projected beam to traverse along an elliptical trajectory, as can be seen on an IR card [Fig. 5(a)]. Figure 5(b) shows the center part of the scanning trajectory (6.8-deg projection angle) taken at with an exposure time . We measure the intensity distribution across the trajectory (averaging along the trajectory line), which is identical to the 1D intensity distribution of the scanning beam at specific positions. As shown in Fig. 5(c), the 1D intensity distribution of the beam spot without fiber actuation (correspond to 0-deg projection angle) has no observable difference compared with that of the trajectory line of the scanning beam with a small (6.8 deg) projection angle. As the objective lens of our microscope has a small NA of only 0.24, it cannot directly image the beam with projection angles . To image the trajectory of the scanning beam at , a frost film is placed at the focal plane of the microscope to scatter the light. Figure 5(d) shows the image of beam trajectory on a frost film. The scattering of the frost film causes a slight broadening () of the FWHM of the intensity distribution. This excess broadening is removed to recover the actual FWHM.
The scanning trajectory at different positions in the plane has different corresponding beam projection angles, as demonstrated in Fig. 5(e). Therefore, to measure the FWHM of the beam at different projection angles, we move the microscope in the plane to take images of different parts of the elliptical scanning trajectory. We scan over a small and large FOV, whose trajectories are high aspect ratio ellipses that cover the projection angle range 6.2 deg to 20.6 deg and 13.7 deg to 35.0 deg [Fig. 5(e)], respectively. We compared the measured FWHM of the scanning beam versus beam projection angle with the simulation results obtained in Zemax (FWHM of the 1D cross section of the PSF calculated by Huygens method) in Fig. 5(f). It is worth noticing that at the projection angle , the beam intensity distribution is not centrosymmetric due to the oblique incidence of the beam, which results in beam distortions shown in Fig. 5(g). Specifically, two different distributions along two orthogonal axes arise, which we define as radial and tangential axis. The radial axis connects the beam spot to center (intersection of the optical axis and the plane), and the axis perpendicular to that is defined as the tangential axis. As shown in Fig. 5(e), the intensity distribution across the trajectory is the radial distribution of the scanning beam at the co-vertex of the ellipse (smallest beam projection angle), and is close to the tangential distribution of the beam near the vertex of the ellipse (large beam projection angle). As shown in Fig. 5(f), for both small and large FOV scan, the measured FWHMs at the smallest projection angles of the scans (co-vertex position) are close to the simulated radial FWHMs, whereas at large projection angles of the scans (near to vertex), the measured FWHMs are close to the simulated tangential FWHMs. Therefore, we demonstrate that the measured FWHMs of the scanning beam at various projection angles within the 35-deg half-FOV match well with the simulation. According to the simulation, for our metalens, at the center of the field (0-deg projection angle), the FWHM of the beam is ; the tangential and radial FWHM of the beam increase by 29% and 86%, respectively, at the edge of the FOV (35-deg projection angle). In contrast, when using the state-of-the-art spherical refractive lens doublet [design in Fig. 2(b)], simulations show that the FWHM of the beam is slightly smaller at the center of the field (), but the tangential FWHM of the beam increased by over 187% to at the edge of the FOV due to the spherical aberration. The FWHM of the scanning projected beam determines the spatial resolution of our SFE system. Therefore, our metalens SFE system can achieve a comparable resolution of the state-of-the-art SFE at the center of the field, but outperforms the state-of-the-art at the edge of the FOV as it suffers significantly less from resolution degradation (less than a factor of 2).
4. Conclusion
We realized a metalens, suitable for integration and miniaturization of an SFE. We demonstrated an SFE system at 1310 nm with large FOV and DOF. Our metalens SFE system can reach an FOV of 70 deg, a DOF of , and a spatial resolution of at an illumination distance up to 15 mm at the center of the field, which is comparable with the state-of-the-art. The length of the optics is reduced by 28% (from 1.2 to 0.86 mm), and resolution degradation at the edge of the FOV is reduced to less than a factor of 2. Further device length reduction is possible using a thinner substrate and increasing the NA of the fiber. In addition, the current forward-view design might be modulated to realize side-view imaging. This can be done using a reflective metalens17 instead of the transmissive one, and placing it at 45 deg relative to the free-standing fiber. We also note that, while our current implementation employs a single wavelength, using polychromatic metalenses operating in red, green, and blue wavelengths, full color visible SFE can be realized. This could be achieved, for instance by meta-atom engineering, using a scatterer that simultaneously satisfies the phase-profile for multiple wavelengths as demonstrated in the visible range for aperture and NA of .18 Although, these lenses may suffer from a lower focusing efficiency, this could be compensated by increasing the power of the illumination source. We note that in the SFE application, a larger FOV than the reported polychromatic metalenses is needed. However, in SFE, at each beam projection angle, the beam is limited to only a small fraction of the lens, which would reduce the difficulties for large FOV design. Along with meta-atom engineering, other inverse design approaches can be employed, where full-color can be preserved.13
Acknowledgments
The work was supported by the National Science Foundation (NSF), grant no. GCR 2120774. Part of this work was conducted at the Washington Nanofabrication Facility/Molecular Analysis Facility, a National Nanotechnology Coordinated Infrastructure site at the University of Washington with partial support from the NSF (award nos. NNCI-1542101 and NNCI-2025489). The authors thank Dr. Luis Savastano for providing the SFE angioscope image in Fig. 1.
Biographies
Ningzhi Xie is a PhD student in the Department of Electrical and Computer Engineering at the University of Washington. He received his BS degree in physics from the University of Science and Technology of China in 2017, and his MS degree in material science from the University of Pennsylvania in 2019. His current research interests are metaoptics and its applications in miniaturized imaging systems.
Matthew D. Carson is a research engineer in the Human Photonics Lab at the University of Washington. He received his BS degree in physics from the University of Washington in 1990. He currently works on mechanical and electrical system design and testing.
Johannes E. Fröch is a postdoctoral researcher in the Departments of Electrical and Computer Engineering, and Physics at the University of Washington. He received his BSc and MSc degrees from Technical University of Graz, Austria, in 2014 and 2016, respectively, and subsequently completed his PhD at the University of Technology, Sydney, Australia, in 2021. His research interests include nanophotonics and their applications.
Arka Majumdar is an associate professor in the Departments of Electrical and Computer Engineering, and Physics, at the University of Washington. He received his BTech degree from IIT Kharagpur in 2007, where he was honored with the President’s Gold Medal. He received his MS and PhD degrees in electrical engineering from Stanford University in 2009 and 2012, respectively. He spent one year at the University of California, Berkeley (2012–2013), as a postdoc before joining Intel Labs (2013–2014). His research interests include developing a hybrid nanophotonic platform using emerging material systems for optical information science, imaging, and microscopy.
Eric J. Seibel is a research professor in the Department of Mechanical Engineering at the University of Washington with adjunct appointments in Departments of Bioengineering, Electrical and Computer Engineering, and Oral Health Sciences. He received his BS degree from Cornell University in 1983 and his MS degree from University of California, Berkeley, in 1984. After working in the ophthalmic device industry, he graduated with a PhD in bioengineering from the University of Washington, Seattle, in 1996. As director of the Human Photonics Lab at the University of Washington since 2006, his research has been inventing and developing biomedical optical instruments and medical devices.
Karl F. Böhringer received his Dipl.-Inform. degree from the University of Karlsruhe, Germany and his MS and PhD degrees in computer science from Cornell University. He is a professor of Departments of Electrical and Computer Engineering, and Bioengineering at the University of Washington, where his research focuses on micro-/nanoelectromechanical systems, self-assembly, microfluidics, and micro-optics. He is the director of the Institute for Nano-Engineered Systems (NanoES) and site director of the NSF National Nanotechnology Coordinated Infrastructure (NNCI) site at the University of Washington.
Disclosures
Eric Seibel is the consultant to VerAvanti Inc., Redmond, Washington, which has University of Washington license for the SFE. Arka Majumdar and Karl F. Böhringer are co-founder of Tunoptix, which is looking into commercializing metaoptics.
Contributor Information
Ningzhi Xie, Email: nzxie@uw.edu.
Matthew D. Carson, Email: mdc34@uw.edu.
Johannes E. Fröch, Email: jfroech@uw.edu.
Arka Majumdar, Email: arka@uw.edu.
Eric J. Seibel, Email: eseibel@uw.edu.
Karl F. Böhringer, Email: karlb@uw.edu.
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