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Supporting information for Hurgin et al. (2002) Proc. Natl. Acad. Sci. USA, 10.1073/pnas.262663399

Fig. 6. Kinetics of IL-18BP induction and synergy with tumor necrosis factor α (TNF-α) and IL-6. (A) IFN-γ induces IL-18BP in a dose- and time-dependent manner in human WISH cells. Cells were incubated with the indicated concentrations of IFN-γ for 24 and 48 h. (B) Synergistic effects of TNF-α IL-6, and their combination on IFN-γ-induced IL-18BP. HepG2 cells were incubated with the indicated combinations of IFN-γ (100 units/ml), TNF-α (20 ng/ml), and IL-6 (300 units/ml). Induction of IL-18BP by each combination was significantly higher (P < 0.05) then induction by IFN-γ alone. Data are mean ± SD (n = 3 for A; n = 4 for B).