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Fig. 8. Location of genes and repeat sequences in the mouse MrgABC cluster. REPEATMASKER was used to identify and mask all rodent repeats in 1 Mb of sequence encompassing the mouse MrgABC cluster from NT_039423.1. This masked sequence was then compared to a composite of mouse and rat MrgA, MrgB, and MrgC coding exon sequences with PIPMAKER (1). This allowed us to identify the location of the coding exon for each Mrg. mMrgA1-3, mMrgB1, mMrgB4, and mMrgC11 cDNA sequences identified by library screening or 5¢ rapid amplification of cDNA ends were also used to highlight the probable location of the first noncoding exons for most mouse Mrg subfamilies. This comparison also allowed us to predict the average size of the mMrgA (14.3 kb) and mMrgB (8.8 kb) transcription units. The predicted direction of transcription is indicated above each gene. Repeat sequences (see Fig. 7 legend) are overlaid on the genomic sequence. "Eroded" marks the presence of Mrg sequences that contains too many frame-shifts and stop codons for phylogenetic analysis. The locations of fragments too small for phylogenetic classification are also marked.

1. Schwartz, S., Zhang, Z., Frazer, K. A., Smit, A., Riemer, C., Bouck, J., Gibbs, R., Hardison, R. & Miller, W. (2000) Genome Res. 10, 577–586.