|
Table 8. Analysis of HLA class I binding affinity for algorithm-identified peptides derived from selected antigens
A1-supertype.
Binding capacity (IC50 nM) |
Molecules |
|||||
Sequence |
Antigen |
A*0101 |
A*2601 |
A*2902 |
A*3002 |
bound |
KVSDEIWNY |
2 |
435 |
281 |
230 |
1.9 |
4 |
IMNHLMTLY |
5 |
150 |
175 |
1.7 |
1.8 |
4 |
LIENELMNY |
5 |
412 |
228 |
3936 |
161 |
3 |
NVDQQNDMY |
5 |
47 |
-a |
- |
- |
1 |
SSFFMNRFY |
5 |
239 |
166 |
36 |
7.5 |
4 |
NHEQKLSEY |
5 |
- |
- |
- |
- |
0 |
LSEYYDXDIY |
5 |
11 |
- |
1647 |
489 |
2 |
QEEQKKYIY |
5 |
- |
- |
- |
- |
0 |
FQAAESNERY |
12 |
8958 |
3510 |
1780 |
372 |
1 |
QAAESNERY |
12 |
353 |
142 |
- |
3011 |
2 |
ELEASISGKY |
12 |
142 |
23 |
- |
463 |
3 |
LEASISGKY |
12 |
- |
3948 |
- |
87 |
1 |
NLALLYGEY |
12 |
275 |
125 |
138 |
102 |
4 |
SSPLFNNFY |
13 |
117 |
17 |
389 |
41 |
4 |
LNEQLIYTY |
13 |
- |
6211 |
2395 |
4134 |
0 |
QNADKNFLY |
13 |
3811 |
166 |
24 |
663 |
2 |
FVSSIFISFY |
13 |
118 |
11 |
22 |
84 |
4 |
VSSIFISFY |
13 |
144 |
1635 |
1800 |
55 |
2 |
A2 supertype
Binding capacity (IC50 nM) |
Molecules |
||||||
Sequence |
Antigen |
A*0201 |
A*0202 |
A*0203 |
A*0206 |
A*6802 |
bound |
VLRLFVCFLI |
2 |
2744 |
2112 |
299 |
-a |
- |
1 |
FLIFHFFLFL |
2 |
161 |
174 |
2087 |
288 |
475 |
4 |
LIFHFFLFLL |
2 |
200 |
1468 |
3167 |
1562 |
460 |
2 |
FLFLLYILFL |
2 |
2834 |
172 |
2012 |
2113 |
8248 |
1 |
RLPVICSFLV |
2 |
12 |
2.5 |
33 |
19 |
9176 |
4 |
VICSFLVFLV |
2 |
167 |
415 |
2916 |
197 |
1949 |
3 |
FLVFLVFSNV |
2 |
269 |
212 |
35 |
232 |
5393 |
4 |
LIFHFFLFL |
2 |
1304 |
3559 |
8718 |
2791 |
4950 |
0 |
FLLYILFLV |
2 |
346 |
279 |
3091 |
1801 |
6981 |
2 |
VICSFLVFL |
2 |
184 |
19 |
2331 |
236 |
4800 |
3 |
ATYGIIVPV |
2 |
3.2 |
2.0 |
2.8 |
5.0 |
21 |
5 |
VQMMIMIKFM |
5 |
- |
8713 |
- |
1390 |
- |
0 |
MMIMIKFMGV |
5 |
123 |
19 |
25 |
109 |
39 |
5 |
KIYKIIIWI |
5 |
157 |
1179 |
638 |
101 |
2198 |
2 |
YMIKKLLKI |
5 |
105 |
4.6 |
4.7 |
93 |
- |
4 |
LMTLYQIQV |
5 |
14 |
1.6 |
20 |
615 |
1276 |
3 |
FMGVIYIMI |
5 |
13 |
2.1 |
26 |
98 |
- |
4 |
NILIVLYYL |
5 |
- |
1611 |
8779 |
1088 |
- |
0 |
FMNRFYITT |
5 |
101 |
18 |
13 |
996 |
6543 |
3 |
YQDPQNYEL |
12 |
79 |
18 |
441 |
52 |
- |
4 |
KTWKPTIFL |
12 |
135 |
1242 |
7487 |
76 |
3617 |
2 |
LLNESNIFL |
12 |
43 |
2.5 |
24 |
143 |
4484 |
4 |
FIHFFTWGT |
12 |
80 |
4.7 |
64 |
60 |
383 |
5 |
VLFLQMMNV |
13 |
31 |
1.8 |
2.7 |
9.5 |
323 |
5 |
NQMIFVSSI |
13 |
250 |
21 |
3.6 |
14 |
198 |
5 |
MIFVSSIFI |
13 |
85 |
18 |
83 |
114 |
5.2 |
5 |
SIFISFYLI |
13 |
289 |
35 |
1416 |
43 |
18 |
4 |
RLFEESLGI |
13 |
26 |
1.9 |
5.5 |
68 |
418 |
5 |
A3-supertype
Binding capacity (IC50 nM) |
Molecules |
||||||
Sequence |
Antigen |
A*0301 |
A*1101 |
A*3101 |
A*3301 |
A*6801 |
bound |
FLLYILFLVK |
2 |
446 |
1431 |
-a |
3254 |
2266 |
1 |
LLYILFLVK |
2 |
13 |
207 |
- |
- |
5545 |
2 |
LVFSNVLCFR |
2 |
120 |
19 |
33 |
19 |
7.7 |
5 |
AFLESQSMNK |
2 |
3055 |
1089 |
9888 |
- |
- |
0 |
TFLESSFDIK |
2 |
- |
2514 |
- |
- |
- |
0 |
SSFDIKSEVK |
2 |
1900 |
19 |
- |
- |
31 |
2 |
KSMLKELIK |
2 |
189 |
151 |
450 |
- |
- |
3 |
PVLTSLFNK |
2 |
1949 |
25 |
5107 |
- |
- |
1 |
KTMNNYMIK |
5 |
17 |
5.5 |
24 |
- |
29 |
4 |
TLYQIQVMKR |
5 |
361 |
164 |
397 |
558 |
90 |
4 |
KQVQMMIMIK |
5 |
264 |
112 |
4627 |
1231 |
2247 |
2 |
GVIYIMIISK |
5 |
777 |
18 |
- |
1567 |
1134 |
1 |
ELFDKDTFFK |
5 |
144 |
109 |
3676 |
13 |
3.6 |
4 |
LFDKDTFFK |
5 |
931 |
167 |
5706 |
1189 |
101 |
2 |
YLFNQHIKK |
5 |
14 |
7.8 |
4919 |
7974 |
14 |
3 |
MQSSFFMNR |
5 |
13 |
1.1 |
29 |
75 |
3.8 |
5 |
RFYITTRYK |
5 |
1.9 |
67 |
15 |
98 |
- |
4 |
TTRYKYLNK |
5 |
117 |
848 |
416 |
652 |
2565 |
2 |
AVIFTPIYY |
12 |
25 |
10 |
- |
- |
1352 |
2 |
ALERLLSLKK |
12 |
147 |
822 |
- |
- |
- |
1 |
ALERLLSLK |
12 |
233 |
369 |
3433 |
- |
- |
2 |
SISGKYDIK |
12 |
2086 |
50 |
- |
- |
1745 |
1 |
ILCIEGEQK |
12 |
1402 |
641 |
7534 |
- |
526 |
0 |
KILIKIPVTK |
12 |
13 |
60 |
1661 |
- |
- |
2 |
EQRLPLLPK |
12 |
1088 |
765 |
423 |
987 |
1911 |
1 |
RLPLLPKTWK |
12 |
11 |
67 |
340 |
- |
2889 |
3 |
NIFLRFIPDK |
12 |
- |
2115 |
- |
1094 |
1526 |
0 |
IFLRFIPDK |
12 |
2438 |
1275 |
1643 |
1308 |
- |
0 |
SQVSNSDSYK |
12 |
1656 |
83 |
- |
- |
1384 |
1 |
QQNQESKIMK |
12 |
3469 |
77 |
- |
- |
- |
1 |
IIALLIIPPK |
12 |
30 |
5.3 |
- |
8426 |
82 |
3 |
IALLIIPPK |
12 |
1241 |
108 |
2926 |
1404 |
1965 |
1 |
PVVCSMEYK |
12 |
1940 |
80 |
- |
- |
414 |
2 |
VVCSMEYKK |
12 |
443 |
54 |
891 |
- |
167 |
3 |
FSYDLRLNK |
12 |
29 |
4.9 |
461 |
1264 |
15 |
4 |
HLNIPIGFK |
12 |
2.3 |
1.3 |
183 |
97 |
2.8 |
5 |
SQDLACIFDA |
12 |
- |
- |
- |
- |
- |
0 |
SSPLFNNFYK |
13 |
100 |
0.74 |
1608 |
1728 |
6.3 |
3 |
PLFNNFYKR |
13 |
2635 |
1890 |
520 |
1258 |
132 |
1 |
YQNFQNADK |
13 |
2712 |
177 |
- |
- |
- |
1 |
FLYLLNKKNK |
13 |
177 |
475 |
4313 |
780 |
155 |
3 |
LQMMNVNLQK |
13 |
25 |
7.2 |
435 |
1113 |
320 |
4 |
QMMNVNLQK |
13 |
20 |
7.0 |
504 |
6649 |
243 |
3 |
LTNHLINTPK |
13 |
11 |
5.9 |
62 |
373 |
10 |
5 |
AVSEIQNNK |
13 |
25 |
11 |
1429 |
- |
14 |
3 |
GTMYILLKK |
13 |
2.2 |
1.2 |
29 |
8453 |
3.1 |
4 |
IFISFYLINK |
13 |
1987 |
1056 |
462 |
394 |
363 |
3 |
FISFYLINK |
13 |
19 |
9.0 |
2192 |
1456 |
18 |
3 |
YLINKHWQR |
13 |
1034 |
676 |
4.4 |
7.7 |
3.7 |
3 |
ALKISQLQK |
13 |
15 |
96 |
3203 |
- |
- |
2 |
KINSNFLLK |
13 |
17 |
6.4 |
68 |
- |
2737 |
3 |
RLFEESLGIR |
13 |
64 |
1096 |
297 |
788 |
409 |
3 |
A24-supertype.
Binding capacity (IC50 nM) |
Molecules |
|||||
Sequence |
Antigen |
A*2301 |
A*2402 |
A*2902 |
A*3002 |
bound |
LFVCFLIFHF |
2 |
780 |
-a |
- |
- |
0 |
CFLIFHFFLF |
2 |
922 |
3939 |
- |
- |
0 |
HFFLFLLYIL |
2 |
7547 |
- |
9475 |
8475 |
0 |
CFLIFHFFL |
2 |
891 |
- |
- |
- |
0 |
IFHFFLFLL |
2 |
80 |
208 |
1405 |
837 |
2 |
HFFLFLLYI |
2 |
- |
- |
- |
- |
0 |
FFLFLLYIL |
2 |
1462 |
2149 |
1833 |
- |
0 |
LYILFLVKM |
2 |
2878 |
- |
- |
- |
0 |
VFLVFSNVL |
2 |
6.9 |
26 |
- |
- |
2 |
TYGIIVPVL |
2 |
41 |
248 |
- |
1519 |
2 |
NYMKIMNHL |
5 |
1.7 |
16 |
- |
110 |
3 |
SYKSSKRDKF |
5 |
797 |
256 |
- |
88 |
2 |
TYKKKNNHI |
5 |
81 |
30 |
- |
162 |
3 |
VYYNILIVL |
5 |
52 |
265 |
- |
1127 |
2 |
LYYLFNQHI |
5 |
1.4 |
33 |
- |
- |
2 |
SFFMNRFYI |
5 |
11 |
172 |
200 |
1022 |
3 |
FYITTRYKY |
5 |
11 |
350 |
9.6 |
7.5 |
4 |
KYINFINFI |
5 |
0.72 |
11 |
- |
55 |
3 |
NFINFIKVL |
5 |
1041 |
- |
- |
- |
0 |
KYEALIKLL |
5 |
484 |
2856 |
- |
- |
1 |
RYQDPQNYEL |
12 |
124 |
212 |
- |
84 |
2 |
IYYFDGNSW |
12 |
6.1 |
80 |
3101 |
3025 |
2 |
VYRHCEYIL |
12 |
64 |
2200 |
- |
3326 |
1 |
TWKPTIFLL |
12 |
11 |
148 |
- |
306 |
3 |
SYKVNCINF |
12 |
15 |
27 |
2535 |
572 |
2 |
KYNYFIHFF |
12 |
0.49 |
2.5 |
319 |
2.7 |
4 |
NYFIHFFTW |
12 |
1.3 |
9.3 |
9774 |
3020 |
2 |
HFFTWGTMF |
12 |
5.7 |
83 |
4.0 |
220 |
4 |
MFVPKYFEL |
12 |
11 |
266 |
2560 |
8560 |
2 |
IYTIIQDQL |
12 |
45 |
72 |
- |
- |
2 |
DFFLKSKFNI |
13 |
304 |
1648 |
- |
2614 |
1 |
FFLKSKFNI |
13 |
49 |
1434 |
- |
- |
1 |
KFNILSSPL |
13 |
1760 |
1731 |
- |
1277 |
0 |
RMTSLKNEL |
13 |
1807 |
-- |
- |
14 |
1 |
YYNNFNNNY |
13 |
126 |
817 |
19 |
58 |
3 |
YYNKSTEKL |
13 |
106 |
109 |
- |
- |
2 |
EYEPTANLL |
13 |
44 |
127 |
- |
- |
2 |
A dash (-) indicates binding affinity >10,000 nM.