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Table 8. Analysis of HLA class I binding affinity for algorithm-identified peptides derived from selected antigens

A1-supertype.

Binding capacity (IC50 nM)

Molecules

Sequence

Antigen

A*0101

A*2601

A*2902

A*3002

bound

KVSDEIWNY

2

435

281

230

1.9

4

IMNHLMTLY

5

150

175

1.7

1.8

4

LIENELMNY

5

412

228

3936

161

3

NVDQQNDMY

5

47

-a

-

-

1

SSFFMNRFY

5

239

166

36

7.5

4

NHEQKLSEY

5

-

-

-

-

0

LSEYYDXDIY

5

11

-

1647

489

2

QEEQKKYIY

5

-

-

-

-

0

FQAAESNERY

12

8958

3510

1780

372

1

QAAESNERY

12

353

142

-

3011

2

ELEASISGKY

12

142

23

-

463

3

LEASISGKY

12

-

3948

-

87

1

NLALLYGEY

12

275

125

138

102

4

SSPLFNNFY

13

117

17

389

41

4

LNEQLIYTY

13

-

6211

2395

4134

0

QNADKNFLY

13

3811

166

24

663

2

FVSSIFISFY

13

118

11

22

84

4

VSSIFISFY

13

144

1635

1800

55

2

A2 supertype

Binding capacity (IC50 nM)

Molecules

Sequence

Antigen

A*0201

A*0202

A*0203

A*0206

A*6802

bound

VLRLFVCFLI

2

2744

2112

299

-a

-

1

FLIFHFFLFL

2

161

174

2087

288

475

4

LIFHFFLFLL

2

200

1468

3167

1562

460

2

FLFLLYILFL

2

2834

172

2012

2113

8248

1

RLPVICSFLV

2

12

2.5

33

19

9176

4

VICSFLVFLV

2

167

415

2916

197

1949

3

FLVFLVFSNV

2

269

212

35

232

5393

4

LIFHFFLFL

2

1304

3559

8718

2791

4950

0

FLLYILFLV

2

346

279

3091

1801

6981

2

VICSFLVFL

2

184

19

2331

236

4800

3

ATYGIIVPV

2

3.2

2.0

2.8

5.0

21

5

VQMMIMIKFM

5

-

8713

-

1390

-

0

MMIMIKFMGV

5

123

19

25

109

39

5

KIYKIIIWI

5

157

1179

638

101

2198

2

YMIKKLLKI

5

105

4.6

4.7

93

-

4

LMTLYQIQV

5

14

1.6

20

615

1276

3

FMGVIYIMI

5

13

2.1

26

98

-

4

NILIVLYYL

5

-

1611

8779

1088

-

0

FMNRFYITT

5

101

18

13

996

6543

3

YQDPQNYEL

12

79

18

441

52

-

4

KTWKPTIFL

12

135

1242

7487

76

3617

2

LLNESNIFL

12

43

2.5

24

143

4484

4

FIHFFTWGT

12

80

4.7

64

60

383

5

VLFLQMMNV

13

31

1.8

2.7

9.5

323

5

NQMIFVSSI

13

250

21

3.6

14

198

5

MIFVSSIFI

13

85

18

83

114

5.2

5

SIFISFYLI

13

289

35

1416

43

18

4

RLFEESLGI

13

26

1.9

5.5

68

418

5

A3-supertype

Binding capacity (IC50 nM)

Molecules

Sequence

Antigen

A*0301

A*1101

A*3101

A*3301

A*6801

bound

FLLYILFLVK

2

446

1431

-a

3254

2266

1

LLYILFLVK

2

13

207

-

-

5545

2

LVFSNVLCFR

2

120

19

33

19

7.7

5

AFLESQSMNK

2

3055

1089

9888

-

-

0

TFLESSFDIK

2

-

2514

-

-

-

0

SSFDIKSEVK

2

1900

19

-

-

31

2

KSMLKELIK

2

189

151

450

-

-

3

PVLTSLFNK

2

1949

25

5107

-

-

1

KTMNNYMIK

5

17

5.5

24

-

29

4

TLYQIQVMKR

5

361

164

397

558

90

4

KQVQMMIMIK

5

264

112

4627

1231

2247

2

GVIYIMIISK

5

777

18

-

1567

1134

1

ELFDKDTFFK

5

144

109

3676

13

3.6

4

LFDKDTFFK

5

931

167

5706

1189

101

2

YLFNQHIKK

5

14

7.8

4919

7974

14

3

MQSSFFMNR

5

13

1.1

29

75

3.8

5

RFYITTRYK

5

1.9

67

15

98

-

4

TTRYKYLNK

5

117

848

416

652

2565

2

AVIFTPIYY

12

25

10

-

-

1352

2

ALERLLSLKK

12

147

822

-

-

-

1

ALERLLSLK

12

233

369

3433

-

-

2

SISGKYDIK

12

2086

50

-

-

1745

1

ILCIEGEQK

12

1402

641

7534

-

526

0

KILIKIPVTK

12

13

60

1661

-

-

2

EQRLPLLPK

12

1088

765

423

987

1911

1

RLPLLPKTWK

12

11

67

340

-

2889

3

NIFLRFIPDK

12

-

2115

-

1094

1526

0

IFLRFIPDK

12

2438

1275

1643

1308

-

0

SQVSNSDSYK

12

1656

83

-

-

1384

1

QQNQESKIMK

12

3469

77

-

-

-

1

IIALLIIPPK

12

30

5.3

-

8426

82

3

IALLIIPPK

12

1241

108

2926

1404

1965

1

PVVCSMEYK

12

1940

80

-

-

414

2

VVCSMEYKK

12

443

54

891

-

167

3

FSYDLRLNK

12

29

4.9

461

1264

15

4

HLNIPIGFK

12

2.3

1.3

183

97

2.8

5

SQDLACIFDA

12

-

-

-

-

-

0

SSPLFNNFYK

13

100

0.74

1608

1728

6.3

3

PLFNNFYKR

13

2635

1890

520

1258

132

1

YQNFQNADK

13

2712

177

-

-

-

1

FLYLLNKKNK

13

177

475

4313

780

155

3

LQMMNVNLQK

13

25

7.2

435

1113

320

4

QMMNVNLQK

13

20

7.0

504

6649

243

3

LTNHLINTPK

13

11

5.9

62

373

10

5

AVSEIQNNK

13

25

11

1429

-

14

3

GTMYILLKK

13

2.2

1.2

29

8453

3.1

4

IFISFYLINK

13

1987

1056

462

394

363

3

FISFYLINK

13

19

9.0

2192

1456

18

3

YLINKHWQR

13

1034

676

4.4

7.7

3.7

3

ALKISQLQK

13

15

96

3203

-

-

2

KINSNFLLK

13

17

6.4

68

-

2737

3

RLFEESLGIR

13

64

1096

297

788

409

3

A24-supertype.

Binding capacity (IC50 nM)

Molecules

Sequence

Antigen

A*2301

A*2402

A*2902

A*3002

bound

LFVCFLIFHF

2

780

-a

-

-

0

CFLIFHFFLF

2

922

3939

-

-

0

HFFLFLLYIL

2

7547

-

9475

8475

0

CFLIFHFFL

2

891

-

-

-

0

IFHFFLFLL

2

80

208

1405

837

2

HFFLFLLYI

2

-

-

-

-

0

FFLFLLYIL

2

1462

2149

1833

-

0

LYILFLVKM

2

2878

-

-

-

0

VFLVFSNVL

2

6.9

26

-

-

2

TYGIIVPVL

2

41

248

-

1519

2

NYMKIMNHL

5

1.7

16

-

110

3

SYKSSKRDKF

5

797

256

-

88

2

TYKKKNNHI

5

81

30

-

162

3

VYYNILIVL

5

52

265

-

1127

2

LYYLFNQHI

5

1.4

33

-

-

2

SFFMNRFYI

5

11

172

200

1022

3

FYITTRYKY

5

11

350

9.6

7.5

4

KYINFINFI

5

0.72

11

-

55

3

NFINFIKVL

5

1041

-

-

-

0

KYEALIKLL

5

484

2856

-

-

1

RYQDPQNYEL

12

124

212

-

84

2

IYYFDGNSW

12

6.1

80

3101

3025

2

VYRHCEYIL

12

64

2200

-

3326

1

TWKPTIFLL

12

11

148

-

306

3

SYKVNCINF

12

15

27

2535

572

2

KYNYFIHFF

12

0.49

2.5

319

2.7

4

NYFIHFFTW

12

1.3

9.3

9774

3020

2

HFFTWGTMF

12

5.7

83

4.0

220

4

MFVPKYFEL

12

11

266

2560

8560

2

IYTIIQDQL

12

45

72

-

-

2

DFFLKSKFNI

13

304

1648

-

2614

1

FFLKSKFNI

13

49

1434

-

-

1

KFNILSSPL

13

1760

1731

-

1277

0

RMTSLKNEL

13

1807

--

-

14

1

YYNNFNNNY

13

126

817

19

58

3

YYNKSTEKL

13

106

109

-

-

2

EYEPTANLL

13

44

127

-

-

2

A dash (-) indicates binding affinity >10,000 nM.