The fission yeast model for the lysosomal storage disorder Batten disease predicts disease severity caused by mutations in CLN3

DMM000851 Supplementary Material

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• Supplemental Figure S1 -

  Fig. S1. CLN3 orthologues in vertebrates, invertebrates and yeast. Human, mouse, Danio rerio, Drosophila melanogaster and Schizosaccharomyces pombe sequences are shown. Annotations: (=) predicted transmembrane domains, (:) predicted amphipathic helix (Nugent et al., 2008), (^) targeted mutations, (*) disease-causing missense mutations.